Factors associated with low levels of subclinical vascular disease in older adults

Multi-ethnic study of atherosclerosis

Erin Donnelly Michos, Kenneth M. Rice, Moyses Szklo, Gregory L. Burke, David S. Siscovick, Russell P. Tracy, R. Graham Barr, Jennifer A. Nettleton, Philip Greenland, David R. Jacobs, Wendy S Post

Research output: Contribution to journalArticle

Abstract

Coronary artery calcium (CAC), carotid intima-media thickness (CIMT), and reduced ankle brachial indices (ABI) are markers of subclinical vascular disease strongly associated with aging. The authors identified factors associated with low levels of subclinical vascular disease in 1824 participants 70 years and older in the Multi-Ethnic Study of Atherosclerosis. A total of 452 had low CAC (0.9), and 165 had a combination index indicating favorable values for all 3 parameters. This combination index was independently associated with younger age (odds ratio [OR] 2.5 per 1 SD [95% confidence interval (CI), 1.8-3.6]), female sex (OR 3.0 [95% CI, 1.9-4.8]), lower body mass index (OR 1.6 per 1 SD [95% CI, 1.2-2.0]), absence of hypertension (OR 1.8 [95% CI, 1.2-2.6]), absence of dyslipidemia (OR 1.6 [95% CI, 1.04-2.4]), and never-smoking (OR 1.7 [95% CI, 1.1-2.6]). No significant associations were observed for C-reactive protein, education, diet, or physical activity. Favorable levels of multiple traditional risk factors, but not several novel risk factors, were associated with subclinical markers of successful cardiovascular aging.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalPreventive Cardiology
Volume12
Issue number2
DOIs
StatePublished - Mar 2009

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Vascular Diseases
Atherosclerosis
Odds Ratio
Confidence Intervals
Coronary Vessels
Calcium
Ankle Brachial Index
Carotid Intima-Media Thickness
Sex Ratio
Dyslipidemias
C-Reactive Protein
Body Mass Index
Smoking
Diet
Hypertension
Education

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health

Cite this

Factors associated with low levels of subclinical vascular disease in older adults : Multi-ethnic study of atherosclerosis. / Michos, Erin Donnelly; Rice, Kenneth M.; Szklo, Moyses; Burke, Gregory L.; Siscovick, David S.; Tracy, Russell P.; Graham Barr, R.; Nettleton, Jennifer A.; Greenland, Philip; Jacobs, David R.; Post, Wendy S.

In: Preventive Cardiology, Vol. 12, No. 2, 03.2009, p. 72-79.

Research output: Contribution to journalArticle

Michos, Erin Donnelly ; Rice, Kenneth M. ; Szklo, Moyses ; Burke, Gregory L. ; Siscovick, David S. ; Tracy, Russell P. ; Graham Barr, R. ; Nettleton, Jennifer A. ; Greenland, Philip ; Jacobs, David R. ; Post, Wendy S. / Factors associated with low levels of subclinical vascular disease in older adults : Multi-ethnic study of atherosclerosis. In: Preventive Cardiology. 2009 ; Vol. 12, No. 2. pp. 72-79.
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