TY - JOUR
T1 - Factors associated with low levels of subclinical vascular disease in older adults
T2 - Multi-ethnic study of atherosclerosis
AU - Michos, Erin D.
AU - Rice, Kenneth M.
AU - Szklo, Moyses
AU - Burke, Gregory L.
AU - Siscovick, David S.
AU - Tracy, Russell P.
AU - Graham Barr, R.
AU - Nettleton, Jennifer A.
AU - Greenland, Philip
AU - Jacobs, David R.
AU - Post, Wendy
PY - 2009/3
Y1 - 2009/3
N2 - Coronary artery calcium (CAC), carotid intima-media thickness (CIMT), and reduced ankle brachial indices (ABI) are markers of subclinical vascular disease strongly associated with aging. The authors identified factors associated with low levels of subclinical vascular disease in 1824 participants 70 years and older in the Multi-Ethnic Study of Atherosclerosis. A total of 452 had low CAC (<25th percentile), 441 had low CIMT (<25th percentile), 1636 had normal ABI (>0.9), and 165 had a combination index indicating favorable values for all 3 parameters. This combination index was independently associated with younger age (odds ratio [OR] 2.5 per 1 SD [95% confidence interval (CI), 1.8-3.6]), female sex (OR 3.0 [95% CI, 1.9-4.8]), lower body mass index (OR 1.6 per 1 SD [95% CI, 1.2-2.0]), absence of hypertension (OR 1.8 [95% CI, 1.2-2.6]), absence of dyslipidemia (OR 1.6 [95% CI, 1.04-2.4]), and never-smoking (OR 1.7 [95% CI, 1.1-2.6]). No significant associations were observed for C-reactive protein, education, diet, or physical activity. Favorable levels of multiple traditional risk factors, but not several novel risk factors, were associated with subclinical markers of successful cardiovascular aging.
AB - Coronary artery calcium (CAC), carotid intima-media thickness (CIMT), and reduced ankle brachial indices (ABI) are markers of subclinical vascular disease strongly associated with aging. The authors identified factors associated with low levels of subclinical vascular disease in 1824 participants 70 years and older in the Multi-Ethnic Study of Atherosclerosis. A total of 452 had low CAC (<25th percentile), 441 had low CIMT (<25th percentile), 1636 had normal ABI (>0.9), and 165 had a combination index indicating favorable values for all 3 parameters. This combination index was independently associated with younger age (odds ratio [OR] 2.5 per 1 SD [95% confidence interval (CI), 1.8-3.6]), female sex (OR 3.0 [95% CI, 1.9-4.8]), lower body mass index (OR 1.6 per 1 SD [95% CI, 1.2-2.0]), absence of hypertension (OR 1.8 [95% CI, 1.2-2.6]), absence of dyslipidemia (OR 1.6 [95% CI, 1.04-2.4]), and never-smoking (OR 1.7 [95% CI, 1.1-2.6]). No significant associations were observed for C-reactive protein, education, diet, or physical activity. Favorable levels of multiple traditional risk factors, but not several novel risk factors, were associated with subclinical markers of successful cardiovascular aging.
UR - http://www.scopus.com/inward/record.url?scp=64249166526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64249166526&partnerID=8YFLogxK
U2 - 10.1111/j.1751-7141.2008.00023.x
DO - 10.1111/j.1751-7141.2008.00023.x
M3 - Article
C2 - 19476580
AN - SCOPUS:64249166526
SN - 1520-037X
VL - 12
SP - 72
EP - 79
JO - Preventive cardiology
JF - Preventive cardiology
IS - 2
ER -