Factors Associated with Liver Biopsy Performance in HCV-HIV Coinfected Injecting Drug Users with HCV Viremia: Results from a Five-Year Longitudinal Assessment

Dominique Rey, Maria Patrizia Carrieri, Bruno Spire, Sandrine Loubière, Pierre Dellamonica, Hervé Gallais, Gilles Patrice Cassuto, Jean Albert Gastaut, Yolande Obadia, C. Boirot, A. D. Bouhnik, J. P. Cassuto, M. Chesney, P. Dujardin, S. Duran, J. G. Fuzibet, G. Lepeu, D. A. Loundou, C. Marimoutou, D. MechaliJ. P. Moatti, J. Moreau, M. Nègre, I. Poizot-Martin, C. Pradier, C. Rouzioux, A. Sobel, F. Trémolières, D. Vlahov

    Research output: Contribution to journalArticle

    Abstract

    The last international consensus conference about hepatitis C virus (HCV) treatment emphasized the importance of treatment for persons coinfected witb HCV and buman immunodeficiency virus (HIV). As liver biopsy precedes treatment, we aimed to identify factors associated with the performance of liver biopsy among HIV-HCV coinfected drug users during a 5-year follow-up to study their access to HCV treatment. Of the 296 patients followed in the HIV hospital departments of Nice and Marseilles and with retrievable records about HCV diagnosis and care, 166 were eligible for analysis having bad detectable HCV RNA at least once during the study period. Overall, 45.2% of patients underwent liver biopsy during follow-up. Using proportional bazard models, predictors of having had a liver biopsy were high social support, complete abstinence from drug injection, and lack of immunosuppression as well as male gender, no history of multiple incarcerations, more recent onset of drug use, and an increase of liver enzyme levels. These results suggest that specific efforts should be devoted to HIV-HCV coinfected drug users to assist with stabilizing these patients to optimize their access to HCV care whenever possible.

    Original languageEnglish (US)
    Pages (from-to)48-57
    Number of pages10
    JournalJournal of Urban Health
    Volume81
    Issue number1
    DOIs
    StatePublished - Mar 1 2004

    Keywords

    • Cohort study
    • Drug use
    • HCV
    • HIV
    • Liver biopsy

    ASJC Scopus subject areas

    • Health(social science)
    • Urban Studies
    • Public Health, Environmental and Occupational Health

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