Factors associated with incident self-reported AIDS among women enrolled in the women's interagency HIV study (WIHS)

N. A. Hessol, K. Anastos, A. M. Levine, N. Ameli, M. Cohen, M. Young, M. Augenbraun, P. Miotti, Stephen J Gange

Research output: Contribution to journalArticle

Abstract

We evaluated factors associated with incident self-reported AIDS diagnoses among HIV-infected women in the Women's Interagency HIV Study (WIHS). Baseline information included age, race/ethnicity, HIV risk category, site of enrollment, years of education, cigarette smoking, CD4 cell count, and HIV viral load. Baseline and follow-up data on self-reported AIDS were analyzed using chi-square, Kaplan-Meier, and Cox proportional hazard models. Among the 1397 HIV-infected women who reported being free of clinical AIDS at baseline, 335 women (24%) reported an incident AIDS diagnosis during follow-up. In stratified Kaplan-Meier analyses, the development of self-reported AIDS was significantly associated with baseline CD4 cell count and viral load (p <0.01). In multivariate Cox proportional hazard analyses, women were statistically more likely to report AIDS if they had CD4 cell counts below 195 cells/mm3 (p <0.01), HIV RNA >4000 copies/ml (p <0.01), were current smokers (p <0.01), and had 'no identifiable risk' for acquisition of HIV (p = 0.03). Self-reports of a clinical AIDS diagnosis may not always be accurate, but laboratory markers of HIV disease indicate that those women who self-report such diagnoses have greater immunodeficiency and a higher viral load when compared with those who report no AIDS-defining diagnoses.

Original languageEnglish (US)
Pages (from-to)1105-1111
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume16
Issue number12
DOIs
StatePublished - Aug 10 2000

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Acquired Immunodeficiency Syndrome
HIV
Viral Load
CD4 Lymphocyte Count
Self Report
Kaplan-Meier Estimate
Proportional Hazards Models
Biomarkers
Smoking
Education

ASJC Scopus subject areas

  • Immunology
  • Virology

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Factors associated with incident self-reported AIDS among women enrolled in the women's interagency HIV study (WIHS). / Hessol, N. A.; Anastos, K.; Levine, A. M.; Ameli, N.; Cohen, M.; Young, M.; Augenbraun, M.; Miotti, P.; Gange, Stephen J.

In: AIDS Research and Human Retroviruses, Vol. 16, No. 12, 10.08.2000, p. 1105-1111.

Research output: Contribution to journalArticle

Hessol, N. A. ; Anastos, K. ; Levine, A. M. ; Ameli, N. ; Cohen, M. ; Young, M. ; Augenbraun, M. ; Miotti, P. ; Gange, Stephen J. / Factors associated with incident self-reported AIDS among women enrolled in the women's interagency HIV study (WIHS). In: AIDS Research and Human Retroviruses. 2000 ; Vol. 16, No. 12. pp. 1105-1111.
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