Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort

Kyle T. Bernstein; Lisa P. Jacobson; Frank J. Jenkins; David Vlahov; Haroutune K. Armenian

doi:10.1097/00007435-200303000-00004

Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort

Kyle T. Bernstein, Lisa P. Jacobson, Frank J. Jenkins, David Vlahov, Haroutune K. Armenian

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations. Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs. Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection. Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085). Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Sexually transmitted diseases
Volume	30
Issue number	3
DOIs	https://doi.org/10.1097/00007435-200303000-00004
State	Published - Mar 1 2003

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases

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title = "Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort",

abstract = "Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations. Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs. Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection. Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085). Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.",

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AU - Bernstein, Kyle T.

AU - Jacobson, Lisa P.

AU - Jenkins, Frank J.

AU - Vlahov, David

AU - Armenian, Haroutune K.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations. Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs. Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection. Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085). Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.

AB - Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations. Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs. Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection. Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085). Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.

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Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort

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