@article{90af68d521364ad9b25974e1c576d60b,
title = "Factors associated with fatality during the intensive phase of anti-tuberculosis treatment",
abstract = "Objective: To determine the case-fatality rate (CFR) at the end of the intensive phase of tuberculosis (TB) treatment, and factors associated with fatality. Methods: TB patients diagnosed between 2006 and 2013 were followed-up during treatment. We computed the CFR at the end of the intensive phase of TB treatment, and the incidence of death per 100 person-days (pd) of follow-up. We performed survival analysis using the Kaplan-Meier method and Cox regression, and calculate hazard ratios (HR) and 95% confidence intervals (CI). Results: A total of 5,182 patients were included, of whom 180 (3.5%) died; 87 of these deaths (48.3%) occurred during the intensive phase of treatment, with a CFR of 1.7%. The incidence of death was 0.028/100 pd. The following factors were associated with death during the intensive phase: being >50 years (HR = 36.9;CI:4.8-283.4); being retired (HR = 2.4; CI:1.1-5.1); having visited the emergency department (HR = 3.1;CI:1.2-7.7); HIV infection (HR = 3.4;CI:1.6-7.2); initial standard treatment with 3 drugs (HR = 2.0;CI:1.2-3.3) or non-standard treatments (HR = 2.68;CI:1.36-5.25); comprehension difficulties (HR = 2.8; CI:1.3-6.1); and smear-positive sputum (HR = 2.3-CI:1.0-4.8). Conclusion: There is a non-negligible CFR during the intensive phase of TB, whose reduction should be prioritised. The CFR could be a useful indicator for evaluating TB programs.",
author = "{Working Group of the Integrated Programme of Tuberculosis Research} and T. Rodrigo and M. Casals and Caminero, {J. A.} and Garc{\'i}a-Garc{\'i}a, {J. M.} and Jim{\'e}nez-Fuentes, {M. A.} and Medina, {J. F.} and Millet, {J. P.} and J. Ruiz-Manzano and J. Cayl{\'a} and R. Ag{\"u}ero and Alc{\'a}zar, {J. L.} and N. Altet and L. Altube and {{\'A}lvarez Navascu{\'e}s}, F. and L. Anibarro and M. Barr{\'o}n and P. Berm{\'u}dez and R. Blanquer and L. Border{\'i}as and A. Bustamante and Calpe, {J. L.} and Caminero, {J. A.} and F. Ca{\~n}as and F. Casas and X. Casas and E. Cases and R. Castrodeza and Cebri{\'a}n, {J. J.} and Ciruelos, {J. E.} and Delgado, {A. E.} and {De Souza}, {M. L.} and D. D{\'i}az and B. Fern{\'a}ndez and A. Fern{\'a}ndez and J. Gallardo and M. Gallego and {Garc{\'i}a Clemente}, {M. M.} and C. Garc{\'i}a and Garc{\'i}a, {F. J.} and Garros, {F. J.} and A. Guerediaga and Gull{\'o}n, {J. A.} and C. Hidalgo and M. Iglesias and G. Jim{\'e}nez and Jim{\'e}nez, {M. A.} and Kindelan, {J. M.} and J. Laparra and R. Lera and T. Lloret",
note = "Publisher Copyright: {\textcopyright} 2016 Rodrigo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = aug,
day = "1",
doi = "10.1371/journal.pone.0159925",
language = "English (US)",
volume = "11",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",
}