TY - JOUR
T1 - Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and hispanic-CRIC studies
AU - Fischer, Michael J.
AU - Xie, Dawei
AU - Jordan, Neil
AU - Kop, Willem J.
AU - Krousel-Wood, Marie
AU - Kurella Tamura, Manjula
AU - Kusek, John W.
AU - Ford, Virginia
AU - Rosen, Leigh K.
AU - Strauss, Louise
AU - Teal, Valerie L.
AU - Yaffe, Kristine
AU - Powe, Neil R.
AU - Lash, James P.
N1 - Funding Information:
Support: In addition to funding under a cooperative agreement from the National Institute of Diabetes and Digestive and Kidney Diseases ( 5U01DK060990 , 5U01DK060984 , 5U01DK06102 , 5U01DK061021 , 5U01DK061028 , 5U01DK60980 , 5U01DK060963 , and 5U01DK060902 ) and R01 DK072231 (H-CRIC), this work was supported in part by the following institutional Clinical Translational Science Awards (CTSA) and other National Institutes of Health (NIH) grants: Johns Hopkins University UL1 RR-025005 , University of Maryland GRCR M01 RR-16500 , Case Western Reserve University Clinical and Translational Science Collaborative (University Hospitals of Cleveland, Cleveland Clinic Foundation, and MetroHealth) UL1 RR-024989 , University of Michigan GCRC M01 RR-000042 , CTSA UL1 RR-024986 , University of Illinois at Chicago Clinical Research Center , M01 RR-013987-06 , Tulane/LSU/Charity Hospital General Clinical Research Center RR-05096 , and Kaiser NIH/National Center for Research Resources UCSF-CTSI UL1 RR-024131 , 5K24DK002651 . Additional support provided by the National Center for Minority Health and Health Disparities, NIH, and Department of Veterans Affairs Health Services Research and Development Service (Career Development Award to Dr Fischer).
PY - 2012/7
Y1 - 2012/7
N2 - Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score <11) and antidepressant medication use. Results: Of 3,853 participants, 27.4% had evidence of elevated depressive symptoms and 18.2% were using antidepressant medications; 31.0% of persons with elevated depressive symptoms were using antidepressants. The prevalence of elevated depressive symptoms varied by level of kidney function: 23.6% for participants with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 and 33.8% of those with eGFR <30 mL/min/1.73 m 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95% CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95% CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P < 0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.
AB - Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score <11) and antidepressant medication use. Results: Of 3,853 participants, 27.4% had evidence of elevated depressive symptoms and 18.2% were using antidepressant medications; 31.0% of persons with elevated depressive symptoms were using antidepressants. The prevalence of elevated depressive symptoms varied by level of kidney function: 23.6% for participants with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 and 33.8% of those with eGFR <30 mL/min/1.73 m 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95% CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95% CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P < 0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.
KW - Depression
KW - antidepressants
KW - chronic kidney disease
KW - disparities
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U2 - 10.1053/j.ajkd.2011.12.033
DO - 10.1053/j.ajkd.2011.12.033
M3 - Article
C2 - 22497791
AN - SCOPUS:84862636176
SN - 0272-6386
VL - 60
SP - 27
EP - 38
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -