Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and hispanic-CRIC studies

Michael J. Fischer, Dawei Xie, Neil Jordan, Willem J. Kop, Marie Krousel-Wood, Manjula Kurella Tamura, John W. Kusek, Virginia Ford, Leigh K. Rosen, Louise Strauss, Valerie L. Teal, Kristine Yaffe, Neil R. Powe, James P. Lash

Research output: Contribution to journalArticle

Abstract

Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score 2 and 33.8% of those with eGFR 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95% CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95% CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P <0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalAmerican Journal of Kidney Diseases
Volume60
Issue number1
DOIs
StatePublished - Jul 2012
Externally publishedYes

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Chronic Renal Insufficiency
Hispanic Americans
Antidepressive Agents
Cohort Studies
Depression
Equipment and Supplies
Albumins
Cross-Sectional Studies
Regression Analysis
Demography
Urine
Kidney
Health

Keywords

  • antidepressants
  • chronic kidney disease
  • Depression
  • disparities

ASJC Scopus subject areas

  • Nephrology

Cite this

Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and hispanic-CRIC studies. / Fischer, Michael J.; Xie, Dawei; Jordan, Neil; Kop, Willem J.; Krousel-Wood, Marie; Kurella Tamura, Manjula; Kusek, John W.; Ford, Virginia; Rosen, Leigh K.; Strauss, Louise; Teal, Valerie L.; Yaffe, Kristine; Powe, Neil R.; Lash, James P.

In: American Journal of Kidney Diseases, Vol. 60, No. 1, 07.2012, p. 27-38.

Research output: Contribution to journalArticle

Fischer, MJ, Xie, D, Jordan, N, Kop, WJ, Krousel-Wood, M, Kurella Tamura, M, Kusek, JW, Ford, V, Rosen, LK, Strauss, L, Teal, VL, Yaffe, K, Powe, NR & Lash, JP 2012, 'Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and hispanic-CRIC studies', American Journal of Kidney Diseases, vol. 60, no. 1, pp. 27-38. https://doi.org/10.1053/j.ajkd.2011.12.033
Fischer, Michael J. ; Xie, Dawei ; Jordan, Neil ; Kop, Willem J. ; Krousel-Wood, Marie ; Kurella Tamura, Manjula ; Kusek, John W. ; Ford, Virginia ; Rosen, Leigh K. ; Strauss, Louise ; Teal, Valerie L. ; Yaffe, Kristine ; Powe, Neil R. ; Lash, James P. / Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and hispanic-CRIC studies. In: American Journal of Kidney Diseases. 2012 ; Vol. 60, No. 1. pp. 27-38.
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abstract = "Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score 2 and 33.8{\%} of those with eGFR 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95{\%} CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95{\%} CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P <0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.",
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AU - Fischer, Michael J.

AU - Xie, Dawei

AU - Jordan, Neil

AU - Kop, Willem J.

AU - Krousel-Wood, Marie

AU - Kurella Tamura, Manjula

AU - Kusek, John W.

AU - Ford, Virginia

AU - Rosen, Leigh K.

AU - Strauss, Louise

AU - Teal, Valerie L.

AU - Yaffe, Kristine

AU - Powe, Neil R.

AU - Lash, James P.

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N2 - Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score 2 and 33.8% of those with eGFR 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95% CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95% CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P <0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.

AB - Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied. Study Design: Cross-sectional analysis. Settings & Participants: Participants at enrollment into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies. CRIC enrolled Hispanics and non-Hispanics at 7 centers in 2003-2007, and H-CRIC enrolled Hispanics at the University of Illinois in 2005-2008. Measurement: Depressive symptoms measured by Beck Depression Inventory (BDI). Predictors: Demographic and clinical factors. Outcomes: Elevated depressive symptoms (BDI score 2 and 33.8% of those with eGFR 2. Lower eGFR (OR per 10-mL/min/1.73 m 2 decrease, 1.10; 95% CI, 1.04-1.17), and non-Hispanic black race (OR, 1.42; 95% CI, 1.16-1.74) were each associated with increased odds of elevated depressive symptoms after controlling for other factors. In regression analyses incorporating BDI score, whereas female sex was associated with greater odds of antidepressant use, Hispanic ethnicity, non-Hispanic black race, and higher urine albumin levels were associated with decreased odds of antidepressant use (P <0.05 for each). Limitations: Absence of clinical diagnosis of depression and use of nonpharmacologic treatments. Conclusions: Although elevated depressive symptoms were common in individuals with CKD, use of antidepressant medications is low. Individuals of racial and ethnic minority background and with more advanced CKD had a greater burden of elevated depressive symptoms and lower use of antidepressant medications.

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