Factors associated with age-related macular degeneration: An ANALYSIS of DATA from THE fi1r8t NATIONAL health AND nutrition EXAMINATION survey

Jack Goldberg, Gordon Flowerdew, Ellen Smith, Jacob A. Brody, Mark O.M. Tso

Research output: Contribution to journalArticlepeer-review

Abstract

Data from the first National Health and Nutrition Examination Survey collected between 1971 and 1972 were used to determine what factors are associated with the prevalence of age-related macular degeneration. The study was limited to those who were at least 45 years old at the time of the ophthalmology examination. Stratified analysis, adjusting for age, showed that education, systolic blood pressure, past history of hypertension, cerebrovascutar disease, and refractive error were all associated with macular degeneration. With the exception of education, these factors remained statistically significant when simultaneously entered into a logistic regression model. The frequency of consumption of fruits and vegetables rich in vitamins A and C suggested a negative association with the prevalence of macular degeneration after stratified adjustment for age. In a logistic regression analysis, adjusting for demographic and medical factors, the inverse association of vitamin C with age-related macular degeneration was no longer present The frequency of consumption of fruits and vegetables rich in vitamin A remained negatively correlated with age-related macular degeneration even after adjustment for demographic and medical factors.

Original languageEnglish (US)
Pages (from-to)700-710
Number of pages11
JournalAmerican journal of epidemiology
Volume128
Issue number4
DOIs
StatePublished - Oct 1988
Externally publishedYes

Keywords

  • Aging
  • Macular degeneration
  • Vitamin A
  • Vitamin C

ASJC Scopus subject areas

  • Epidemiology

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