Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study

Linda Ahdieh-Grant; Patrick M. Tarwater; Michael F. Schneider; Kathryn Anastos; Mardge Cohen; Ann Khalsa; Howard Minkoff; Mary Young; Ruth M. Greenblatt

doi:10.1097/01.qai.0000138160.91568.19

Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study

Linda Ahdieh-Grant, Patrick M. Tarwater, Michael F. Schneider, Kathryn Anastos, Mardge Cohen, Ann Khalsa, Howard Minkoff, Mary Young, Ruth M. Greenblatt

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We characterized factors and temporal trends associated with discontinuation of highly active antiretroviral therapy (HAART) among 936 HIV-infected women enrolled in the Women's Inter-agency HIV Study. A multivariate analysis of post-HAART initiation exposures found that high HIV RNA levels (relative hazard [RH] = 1.36, P < 0.001) and high depressive symptom scores (RH = 1.53, P = 0.012) were associated with HAART discontinuation. The adjusted hazard of discontinuation was higher in the 2 most recent calendar periods compared with the first (RH =1.61, P = 0.026; RH = 1.56, P = 0.074, respectively). The increasing risk of HAART discontinuation in recent calendar periods and changes in the clinical factors associated with discontinuation reflect ongoing and dynamic shifts in the approach to HAART utilization.

Original language	English (US)
Pages (from-to)	500-503
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	38
Issue number	4
DOIs	https://doi.org/10.1097/01.qai.0000138160.91568.19
State	Published - Apr 1 2005

Keywords

Antiretroviral therapy
Cohort studies
Discontinuation
HIV/AIDS

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/01.qai.0000138160.91568.19

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Ahdieh-Grant, L., Tarwater, P. M., Schneider, M. F., Anastos, K., Cohen, M., Khalsa, A., Minkoff, H., Young, M., & Greenblatt, R. M. (2005). Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study. Journal of Acquired Immune Deficiency Syndromes, 38(4), 500-503. https://doi.org/10.1097/01.qai.0000138160.91568.19

Ahdieh-Grant, L, Tarwater, PM , Schneider, MF, Anastos, K, Cohen, M, Khalsa, A, Minkoff, H, Young, M & Greenblatt, RM 2005, 'Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study', Journal of Acquired Immune Deficiency Syndromes, vol. 38, no. 4, pp. 500-503. https://doi.org/10.1097/01.qai.0000138160.91568.19

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AU - Cohen, Mardge

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Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study

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