Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Jonathan N. Sellin, Dima Suki, Viraat Harsh, Benjamin D. Elder, Daniel K. Fahim, Ian E. McCutcheon, Ganesh Rao, Laurence D. Rhines, Claudio E. Tatsui

Research output: Contribution to journalArticle

Abstract

OBJECT: Spinal metastases account for the majority of bone metastases from thyroid cancer. The objective of the current study was to analyze a series of consecutive patients undergoing spinal surgery for thyroid cancer metastases in order to identify factors that influence overall survival. METHODS: The authors retrospectively reviewed the records of all patients who underwent surgery for spinal metastases from thyroid cancer between 1993 and 2010 at the University of Texas MD Anderson Cancer Center. RESULTS: Forty-three patients met the study criteria. Median overall survival was 15.4 months (95% CI 2.8-27.9 months) based on the Kaplan-Meier method. The median follow-up duration for the 4 patients who were alive at the end of the study was 39.4 months (range 1.7-62.6 months). On the multivariate Cox analysis, progressive systemic disease at spine surgery and postoperative complications were associated with worse overall survival (HR 8.98 [95% CI 3.46-23.30], p < 0.001; and HR 2.86 [95% CI 1.30-6.31], p = 0.009, respectively). Additionally, preoperative neurological deficit was significantly associated with worse overall survival on the multivariate analysis (HR 3.01 [95% CI 1.34-6.79], p = 0.008). Conversely, preoperative embolization was significantly associated with improved overall survival on the multivariate analysis (HR 0.43 [95% CI 0.20-0.94], p = 0.04). Preoperative embolization and longer posterior construct length were significantly associated with fewer and greater complications, respectively, on the univariate analysis (OR 0.24 [95% CI 0.06-0.93] p = 0.04; and OR 1.24 [95% CI 1.02-1.52], p = 0.03), but not the multivariate analysis. CONCLUSIONS: Progressive systemic disease, postoperative complications, and preoperative neurological deficits were significantly associated with worse overall survival, while preoperative spinal embolization was associated with improved overall survival. These factors should be taken into consideration when considering such patients for surgery. Preoperative embolization and posterior construct length significantly influenced the incidence of postoperative complications only on the univariate analysis.

Original languageEnglish (US)
Pages (from-to)419-428
Number of pages10
JournalJournal of Neurosurgery: Spine
Volume23
Issue number4
DOIs
StatePublished - Oct 2015

Keywords

  • Oncology
  • Postsurgical survival
  • Spinal metastasis
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology

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    Sellin, J. N., Suki, D., Harsh, V., Elder, B. D., Fahim, D. K., McCutcheon, I. E., Rao, G., Rhines, L. D., & Tatsui, C. E. (2015). Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma. Journal of Neurosurgery: Spine, 23(4), 419-428. https://doi.org/10.3171/2015.1.SPINE14431