Factors affecting graft survival after adult/child split-liver transplantation: Analysis of the UNOS/OPTN data base

K. W. Lee, Andrew M Cameron, W. R. Maley, Dorry Segev, R. A. Montgomery

Research output: Contribution to journalArticle

Abstract

When considering advocacy of split-liver transplantation, it is important to understand whether comparable outcomes can be achieved. The goal of this study was to identify donor and transplant characteristics predictive of comparable outcomes by risk factor analysis. Using the United Network for Organ Sharing/ Organ Procurement and Transplantation Network data base between January 1996 and May 2006, first time adult/child split cases (568 adults, 508 children) were examined. In multivariate analysis, recipient medical condition (hospitalization), status 1 assignment, ABO incompatibility, donor age (>40 years), donor body weight (≤40 kg), calculated whole graft volume to recipient body weight ratio (cGRWR ≤1.5%) and no sharing between centers were significant risk factors in adult recipients. Recipient diagnosis of tumor, dialysis prior to transplant, recipient body weight (≤6 kg), donor age (>30 years), donor history of cardiac arrest after declaration of death and cold ischemia time (CIT > 6 h) increased the risk of graft failure in pediatric recipients. The livers from young donors showed comparable outcomes to whole deceased liver transplantation (LT) when other transplant-related risk factors were minimized in adult recipients. Reducing CIT is important to obtain comparable outcomes to living donor LT in pediatric recipients.

Original languageEnglish (US)
Pages (from-to)1186-1196
Number of pages11
JournalAmerican Journal of Transplantation
Volume8
Issue number6
DOIs
StatePublished - Jun 2008

Fingerprint

Graft Survival
Liver Transplantation
Tissue Donors
Databases
Body Weight
Transplants
Pediatrics
Cold Ischemia
Tissue and Organ Procurement
Living Donors
Organ Transplantation
Heart Arrest
Statistical Factor Analysis
Dialysis
Hospitalization
Multivariate Analysis
Liver
Neoplasms

Keywords

  • Liver graft survival
  • Risk factors
  • Split liver
  • UNOS

ASJC Scopus subject areas

  • Immunology

Cite this

Factors affecting graft survival after adult/child split-liver transplantation : Analysis of the UNOS/OPTN data base. / Lee, K. W.; Cameron, Andrew M; Maley, W. R.; Segev, Dorry; Montgomery, R. A.

In: American Journal of Transplantation, Vol. 8, No. 6, 06.2008, p. 1186-1196.

Research output: Contribution to journalArticle

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