Factors affecting fibrinolytic potential: Cardiovascular fitness, body composition, and lipoprotein(a)

Linda M. Szymanski, J. Larry Durstine, Paul G. Davis, Marsha Dowda, Russell R. Pate

Research output: Contribution to journalArticle

Abstract

The purpose of the study was to determine the factors that affect basal (resting) and poststressor fibrinolytic activity or potential. Variables of interest included cardiovascular fitness (maximal oxygen consumption [VEO2max]), body fat, body mass index (BMI), and lipids/lipoproteins, including lipoprotein(a) [Lp(a)]. Blood was collected from 46 middle-aged men before and after a maximal exercise test. Pearson and Spearman correlation coefficients were calculated to determine associations between the variables of interest and tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities in the basal state and after stimulation with maximal exercise. Multiple regression analyses were also conducted to determine independent predictors of the fibrinolytic variables. Maximal exercise produced significant increases in t-PA activity and decreases in PAI-1 activity. Postexercise t-PA activity was inversely related to basal PAI-1 activity (r = -.34). V̇O2max was positively correlated with t-PA activity (basal, r = .39; postexercise, r = .67) and inversely related to PAI-1 activity (basal, r = -.41; postexercise, r = - .42). Body fat was correlated with postexercise t-PA activity (r = -.60) and both basal and postexercise PAI-1 activity (r = .42), but the correlation with basal t-PA activity was not significant (P = .058). Postexercise t-PA activity was positively correlated (r = .37) with high-density lipoprotein cholesterol (HDL-C) and negatively correlated (r = -.42) with low-density lipoprotein cholesterol (LDL-C). Basal PAI-1 activity was negatively correlated with HDL-C (r = -.37). Lp(a) was not correlated with any fibrinolytic variable or fitness. Multiple regression analyses showed that V̇O2max was an independent predictor of both basal and postexercise t-PA activity (R2 = .16 and .34, respectively). Triglyceride (TG) levels and V̇O2max were significant independent predictors of PAI-1 activity (R2 = .31). In conclusion, cardiovascular fitness was a strong independent predictor of fibrinolytic potential. In addition, poststressor measures of fibrinolytic potential may provide more information about the fibrinolytic system than basal values.

Original languageEnglish (US)
Pages (from-to)1427-1433
Number of pages7
JournalMetabolism: clinical and experimental
Volume45
Issue number11
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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