Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization

Gunnar Blomqvist, Albert Gjedde, Mark Gutniak, Valdemar Grill, Lennart Widén, Sharon Stone-Elander, Eric Hellstrand

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62±19 (mean±SEM) μmol hg-1 min-1, and the half-saturation constant was found to be 4.1 + 2.3 m M.

Original languageEnglish (US)
Pages (from-to)834-837
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Volume18
Issue number10
DOIs
StatePublished - Oct 1991

Keywords

  • Blood-brain transfer of glucose
  • Hypoglycaemia
  • Menten
  • Michaelis
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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