Facile synthesis of new L-arginine derivatives as substrates for trypsin-like proteases

Yongjun Gao; Yuan C. Lee

doi:10.1081/SCC-200030965

Facile synthesis of new L-arginine derivatives as substrates for trypsin-like proteases

Yongjun Gao, Yuan C. Lee

Research output: Contribution to journal › Article › peer-review

Abstract

Facile and efficient synthetic routes for fluorogenic anilides of L-arginine have been developed. The amide bond formation uses phosphorous oxychloride as a condensing agent. The synthesis is simple, rapid, and affords excellent yields.

Original language	English (US)
Pages (from-to)	3465-3471
Number of pages	7
Journal	Synthetic Communications
Volume	34
Issue number	19
DOIs	https://doi.org/10.1081/SCC-200030965
State	Published - 2004
Externally published	Yes

Keywords

2-Aminobenzoic acid
Fluorogenic substrates
Synthesis
Trypsin

ASJC Scopus subject areas

Organic Chemistry

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10.1081/SCC-200030965

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title = "Facile synthesis of new L-arginine derivatives as substrates for trypsin-like proteases",

abstract = "Facile and efficient synthetic routes for fluorogenic anilides of L-arginine have been developed. The amide bond formation uses phosphorous oxychloride as a condensing agent. The synthesis is simple, rapid, and affords excellent yields.",

keywords = "2-Aminobenzoic acid, Fluorogenic substrates, Synthesis, Trypsin",

author = "Yongjun Gao and Lee, {Yuan C.}",

year = "2004",

doi = "10.1081/SCC-200030965",

language = "English (US)",

volume = "34",

pages = "3465--3471",

journal = "Synthetic Communications",

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T1 - Facile synthesis of new L-arginine derivatives as substrates for trypsin-like proteases

AU - Gao, Yongjun

AU - Lee, Yuan C.

PY - 2004

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AB - Facile and efficient synthetic routes for fluorogenic anilides of L-arginine have been developed. The amide bond formation uses phosphorous oxychloride as a condensing agent. The synthesis is simple, rapid, and affords excellent yields.

KW - 2-Aminobenzoic acid

KW - Fluorogenic substrates

KW - Synthesis

KW - Trypsin

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UR - http://www.scopus.com/inward/citedby.url?scp=5444235658&partnerID=8YFLogxK

U2 - 10.1081/SCC-200030965

DO - 10.1081/SCC-200030965

M3 - Article

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VL - 34

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EP - 3471

JO - Synthetic Communications

JF - Synthetic Communications

IS - 19

ER -

Facile synthesis of new L-arginine derivatives as substrates for trypsin-like proteases

Abstract

Keywords

ASJC Scopus subject areas

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