Facile synthesis of α-substituted acrylate esters

Bunda Hin, Pavel Majer, Takashi Tsukamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of 5-monosubstituted Meldrum's acids with dimethylmethyleneimmonium iodide (Eschenmoser's iodide salt) in methanol gives α-substituted acrylate methyl esters in good yields. Easy access to 5-monosubstituted Meldrum's acids allowed us to synthesize a wide variety of α-substituted acrylate methyl esters. The reaction conditions are mild and tolerate many functional groups commonly used in organic synthesis; thus, this new method has potential as an alternative to conventional preparative methods for α-substituted acrylate esters.

Original languageEnglish (US)
Pages (from-to)7365-7368
Number of pages4
JournalJournal of Organic Chemistry
Volume67
Issue number21
DOIs
StatePublished - Oct 18 2002
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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