Facile incorporation of a phosphatase activity-dependent quinone methide generating motif into phosphotyrosine

Kui Shen, Lixin Qi, Mohini Ravula

Research output: Contribution to journalArticle

Abstract

A novel phosphotyrosine analogue that incorporates a phosphatase activity-dependent quinone methide generating motif is synthesized from tyrosine. Following orthoformylation of the phenol moiety of methyl N-Cbz-tyrosinate, the Fmoc-protected 3-difluoromethyl analogue of phosphotyrosine is obtained by functional group transformations.

Original languageEnglish (US)
Article numberM01909SS
Pages (from-to)3765-3768
Number of pages4
JournalSynthesis
Issue number22
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Phosphotyrosine
Phosphatases
Phosphoric Monoester Hydrolases
Functional groups
Phenols
Phenol
Tyrosine
quinone methide

Keywords

  • Amino acids
  • Fluorine
  • Hydrolyses
  • Phosphates
  • Quinomethanes
  • Quinone methides

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

Cite this

Facile incorporation of a phosphatase activity-dependent quinone methide generating motif into phosphotyrosine. / Shen, Kui; Qi, Lixin; Ravula, Mohini.

In: Synthesis, No. 22, M01909SS, 2009, p. 3765-3768.

Research output: Contribution to journalArticle

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