Abstract
A novel phosphotyrosine analogue that incorporates a phosphatase activity-dependent quinone methide generating motif is synthesized from tyrosine. Following orthoformylation of the phenol moiety of methyl N-Cbz-tyrosinate, the Fmoc-protected 3-difluoromethyl analogue of phosphotyrosine is obtained by functional group transformations.
Original language | English (US) |
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Article number | M01909SS |
Pages (from-to) | 3765-3768 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 22 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Amino acids
- Fluorine
- Hydrolyses
- Phosphates
- Quinomethanes
- Quinone methides
ASJC Scopus subject areas
- Organic Chemistry
- Catalysis