Facile construction of multifunctional nanocarriers using sequential click chemistry for applications in biology

Anjali Sharma, Kevin Neibert, Rishi Sharma, Rami Hourani, Dusica Maysinger, Ashok Kakkar

Research output: Contribution to journalArticlepeer-review

Abstract

Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide "click" reactions are performed in sequence. These carriers are internalized into the cells where they reduce H2O2 induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalMacromolecules
Volume44
Issue number3
DOIs
StatePublished - Feb 8 2011
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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