Abstract
Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide "click" reactions are performed in sequence. These carriers are internalized into the cells where they reduce H2O2 induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.
Original language | English (US) |
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Pages (from-to) | 521-529 |
Number of pages | 9 |
Journal | Macromolecules |
Volume | 44 |
Issue number | 3 |
DOIs | |
State | Published - Feb 8 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Materials Chemistry