Facile construction of multifunctional nanocarriers using sequential click chemistry for applications in biology

Anjali Sharma; Kevin Neibert; Rishi Sharma; Rami Hourani; Dusica Maysinger; Ashok Kakkar

doi:10.1021/ma102354k

Facile construction of multifunctional nanocarriers using sequential click chemistry for applications in biology

Anjali Sharma, Kevin Neibert, Rishi Sharma, Rami Hourani, Dusica Maysinger, Ashok Kakkar

Research output: Contribution to journal › Article › peer-review

Abstract

Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide "click" reactions are performed in sequence. These carriers are internalized into the cells where they reduce H₂O₂ induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.

Original language	English (US)
Pages (from-to)	521-529
Number of pages	9
Journal	Macromolecules
Volume	44
Issue number	3
DOIs	https://doi.org/10.1021/ma102354k
State	Published - Feb 8 2011
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/ma102354k

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abstract = "Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide {"}click{"} reactions are performed in sequence. These carriers are internalized into the cells where they reduce H2O2 induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.",

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AU - Sharma, Anjali

AU - Neibert, Kevin

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AU - Hourani, Rami

AU - Maysinger, Dusica

AU - Kakkar, Ashok

PY - 2011/2/8

Y1 - 2011/2/8

N2 - Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide "click" reactions are performed in sequence. These carriers are internalized into the cells where they reduce H2O2 induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.

AB - Bi-and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (α-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne-azide "click" reactions are performed in sequence. These carriers are internalized into the cells where they reduce H2O2 induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with α-lipoic acid enhance intracellular glutathione (GSH) concentrations.

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Facile construction of multifunctional nanocarriers using sequential click chemistry for applications in biology

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