Fabrication of microfluidic vascular phantoms by laser micromachining

Scott A. Mathews, Long Luu, Jessica C. Ramella-Roman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Imaging of capillary structures and monitoring of blood flow within vasculature is becoming more common in clinical settings. However, very few dynamic phantoms exist which mimic capillary structures. We report the fabrication and testing of microfluidic, vascular phantoms aimed at the study of blood flow. These phantoms are fabricated using low-cost, off-the-shelf materials and require no lithographic processing, stamping, or embossing. Using laser micromachining, complex microfluidic structures can be fabricated in under an hour. The laser system is capable of producing microfluidic features with sizes on the order of tens of microns, over an area of several square centimeters. Because the laser micromachining system is computer controlled and accepts both vector and raster files, the microfluidic structure can be simple, rectilinear patterns or complex, anatomically correct patterns. The microfluidic devices interface with simple off the shelf syringe pumps. The microfluidic devices fabricated with this technique were used for non-invasive monitoring of flow using speckle based techniques.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8367
DOIs
StatePublished - 2012
Externally publishedYes
EventSmart Biomedical and Physiological Sensor Technology IX - Baltimore, MD, United States
Duration: Apr 26 2012Apr 26 2012

Other

OtherSmart Biomedical and Physiological Sensor Technology IX
CountryUnited States
CityBaltimore, MD
Period4/26/124/26/12

Fingerprint

Microtechnology
laser machining
Microfluidics
microfluidic devices
Micromachining
Lab-On-A-Chip Devices
blood flow
shelves
Blood Vessels
Lasers
syringes
stamping
Fabrication
embossing
fabrication
files
pumps
Computer Systems
Syringes
Blood

Keywords

  • capillary phantoms
  • laser microfabrication
  • laser micromachining
  • microfluidics
  • vascular phantoms

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Mathews, S. A., Luu, L., & Ramella-Roman, J. C. (2012). Fabrication of microfluidic vascular phantoms by laser micromachining. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8367). [83670B] https://doi.org/10.1117/12.920805

Fabrication of microfluidic vascular phantoms by laser micromachining. / Mathews, Scott A.; Luu, Long; Ramella-Roman, Jessica C.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8367 2012. 83670B.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mathews, SA, Luu, L & Ramella-Roman, JC 2012, Fabrication of microfluidic vascular phantoms by laser micromachining. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8367, 83670B, Smart Biomedical and Physiological Sensor Technology IX, Baltimore, MD, United States, 4/26/12. https://doi.org/10.1117/12.920805
Mathews SA, Luu L, Ramella-Roman JC. Fabrication of microfluidic vascular phantoms by laser micromachining. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8367. 2012. 83670B https://doi.org/10.1117/12.920805
Mathews, Scott A. ; Luu, Long ; Ramella-Roman, Jessica C. / Fabrication of microfluidic vascular phantoms by laser micromachining. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8367 2012.
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