Abstract
Imaging of capillary structures and monitoring of blood flow within vasculature is becoming more common in clinical settings. However, very few dynamic phantoms exist which mimic capillary structures. We report the fabrication and testing of microfluidic, vascular phantoms aimed at the study of blood flow. These phantoms are fabricated using low-cost, off-the-shelf materials and require no lithographic processing, stamping, or embossing. Using laser micromachining, complex microfluidic structures can be fabricated in under an hour. The laser system is capable of producing microfluidic features with sizes on the order of tens of microns, over an area of several square centimeters. Because the laser micromachining system is computer controlled and accepts both vector and raster files, the microfluidic structure can be simple, rectilinear patterns or complex, anatomically correct patterns. The microfluidic devices interface with simple off the shelf syringe pumps. The microfluidic devices fabricated with this technique were used for non-invasive monitoring of flow using speckle based techniques.
Original language | English (US) |
---|---|
Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 8367 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Event | Smart Biomedical and Physiological Sensor Technology IX - Baltimore, MD, United States Duration: Apr 26 2012 → Apr 26 2012 |
Other
Other | Smart Biomedical and Physiological Sensor Technology IX |
---|---|
Country/Territory | United States |
City | Baltimore, MD |
Period | 4/26/12 → 4/26/12 |
Keywords
- capillary phantoms
- laser microfabrication
- laser micromachining
- microfluidics
- vascular phantoms
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging