@article{1719a1fe5afd4d4b8bc6198d5a0cc1fc,
title = "Fabrication of fillable microparticles and other complex 3D microstructures",
abstract = "Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.",
author = "McHugh, {Kevin J.} and Nguyen, {Thanh D.} and Linehan, {Allison R.} and David Yang and Behrens, {Adam M.} and Sviatlana Rose and Tochka, {Zachary L.} and Tzeng, {Stephany Y.} and Norman, {James J.} and Anselmo, {Aaron C.} and Xian Xu and Stephanie Tomasic and Taylor, {Matthew A.} and Jennifer Lu and Rohiverth Guarecuco and Robert Langer and Ana Jaklenec",
note = "Funding Information: This work was funded by the Bill & Melinda Gates Foundation OPP 1095790. Fellowship support for K.J.M. was provided by the NIH under Ruth L. Kirschstein National Research Service Award (F32EB022416) and for T.D.N. by the Max Planck Society and Alexander von Humboldt Foundation. We acknowledge W. H. Gates, L. Wood, P. Eckhoff, S. Kern, K. Owen, L. Shackelton, C. Karp, B. Nikolic, D. Hartman, and S. Hershenson for their advice and guidance. In addition, we thank the MIT Department of Comparative Medicine and the Koch Institute Swanson Biotechnology Center for technical support, specifically the Animal Imaging and Preclinical Testing and Histology cores, as well as the W.M. Keck Microscopy Facility at the Whitehead Institute. We also thank V. Diadiuk, K. Broderick, D. Jamieson, G. Riggott, and D. Ward in the Microsystems Technology Laboratories (MIT) for help with microfabrication process development, BioDot (Irvine, CA) for developing the ink-jet dispensing system, S. Survilaite for taking release time points, S. Bose for assistance with microfluidic device imaging, D. Vlasic for image processing and generating several of the graphics, and M. Cima and L. Bellan for reviewing the manuscript. This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. This license does not apply to figures, photos, artwork, or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material. T.D.N., R.L., and A.J. devised the concept. T.D.N. and K.J.M. Publisher Copyright: {\textcopyright} 2017, American Association for the Advancement of Science. All rights reserved.",
year = "2017",
month = sep,
day = "15",
doi = "10.1126/science.aaf7447",
language = "English (US)",
volume = "357",
pages = "1138--1142",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6356",
}