F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus

George J Dover, Samuel H. Boyer, Marcus E. Pembrey

Research output: Contribution to journalArticle

Abstract

Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the βs-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

Original languageEnglish (US)
Pages (from-to)1441-1444
Number of pages4
JournalScience
Volume212
Issue number4489
StatePublished - 1981

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Reticulocytes
Sickle Cell Anemia
Hemoglobins
Genes
Population
Anemia
Parents
Alleles

ASJC Scopus subject areas

  • General

Cite this

F-cell production in sickle cell anemia : Regulation by genes linked to β-hemoglobin locus. / Dover, George J; Boyer, Samuel H.; Pembrey, Marcus E.

In: Science, Vol. 212, No. 4489, 1981, p. 1441-1444.

Research output: Contribution to journalArticle

Dover, GJ, Boyer, SH & Pembrey, ME 1981, 'F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus', Science, vol. 212, no. 4489, pp. 1441-1444.
Dover, George J ; Boyer, Samuel H. ; Pembrey, Marcus E. / F-cell production in sickle cell anemia : Regulation by genes linked to β-hemoglobin locus. In: Science. 1981 ; Vol. 212, No. 4489. pp. 1441-1444.
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