F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus

George J. Dover, Samuel H. Boyer, Marcus E. Pembrey

Research output: Contribution to journalArticlepeer-review

Abstract

Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the βs-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

Original languageEnglish (US)
Pages (from-to)1441-1444
Number of pages4
JournalScience
Volume212
Issue number4489
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • General

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