Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma

Leandro J. Chaves, Bradley Huth, James J. Augsburger, Zelia Correa

Research output: Contribution to journalArticle

Abstract

The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalOcular Oncology and Pathology
Volume4
Issue number4
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

Fingerprint

Melanoma
Neoplasms
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Neoplasm Staging
Brachytherapy
Therapeutics
Lymph Nodes
Recurrence
Equipment and Supplies
Survival

Keywords

  • Brachytherapy
  • Enucleation
  • Melanoma, conjunctiva
  • Melanoma, eye

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma. / Chaves, Leandro J.; Huth, Bradley; Augsburger, James J.; Correa, Zelia.

In: Ocular Oncology and Pathology, Vol. 4, No. 4, 01.06.2018, p. 261-266.

Research output: Contribution to journalArticle

Chaves, Leandro J. ; Huth, Bradley ; Augsburger, James J. ; Correa, Zelia. / Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma. In: Ocular Oncology and Pathology. 2018 ; Vol. 4, No. 4. pp. 261-266.
@article{2d11c8cfa4e64b2184360a141fad3837,
title = "Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma",
abstract = "The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up.",
keywords = "Brachytherapy, Enucleation, Melanoma, conjunctiva, Melanoma, eye",
author = "Chaves, {Leandro J.} and Bradley Huth and Augsburger, {James J.} and Zelia Correa",
year = "2018",
month = "6",
day = "1",
doi = "10.1159/000485978",
language = "English (US)",
volume = "4",
pages = "261--266",
journal = "Ocular Oncology and Pathology",
issn = "2296-4681",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma

AU - Chaves, Leandro J.

AU - Huth, Bradley

AU - Augsburger, James J.

AU - Correa, Zelia

PY - 2018/6/1

Y1 - 2018/6/1

N2 - The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up.

AB - The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up.

KW - Brachytherapy

KW - Enucleation

KW - Melanoma, conjunctiva

KW - Melanoma, eye

UR - http://www.scopus.com/inward/record.url?scp=85051361377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051361377&partnerID=8YFLogxK

U2 - 10.1159/000485978

DO - 10.1159/000485978

M3 - Article

C2 - 30643772

AN - SCOPUS:85051361377

VL - 4

SP - 261

EP - 266

JO - Ocular Oncology and Pathology

JF - Ocular Oncology and Pathology

SN - 2296-4681

IS - 4

ER -