Eye Movement Research in the Twenty-First Century—a Window to the Brain, Mind, and More

Aasef G. Shaikh, David Samuel Zee

Research output: Contribution to journalArticle

Abstract

The study of eye movements not only addresses debilitating neuro-ophthalmological problems but has become an essential tool of basic neuroscience research. Eye movements are a classic way to evaluate brain function—traditionally in disorders affecting the brainstem and cerebellum. Abnormalities of eye movements have localizing value and help narrow the differential diagnosis of complex neurological problems. More recently, using sophisticated behavioral paradigms, measurement of eye movements has also been applied to disorders of the thalamus, basal ganglia, and cerebral cortex. Moreover, in contemporary neuroscience, eye movements play a key role in understanding cognition, behavior, and disorders of the mind. Examples include applications to higher-level decision-making processes as in neuroeconomics and psychiatric and cognitive disorders such as schizophrenia and autism. Eye movements have become valued as objective biomarkers to monitor the natural progression of disease and the effects of therapies. As specific genetic defects are identified for many neurological disorders, ocular motor function often becomes the cornerstone of phenotypic classification and differential diagnosis. Here, we introduce other important applications of eye movement research, including understanding movement disorders affecting the head and limbs. We also emphasize the need to develop standardized test batteries for eye movements of all types including the vestibulo-ocular responses. The evaluation and treatment of patients with cerebellar ataxia are particularly amenable to such an approach.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCerebellum
DOIs
StateAccepted/In press - Dec 19 2017

Fingerprint

Eye Movements
Brain
Research
Neurosciences
Eye Movement Measurements
Differential Diagnosis
Cognition Disorders
Basal Ganglia Diseases
Cerebellar Ataxia
Movement Disorders
Autistic Disorder
Nervous System Diseases
Thalamus
Mental Disorders
Cerebral Cortex
Cerebellum
Brain Stem
Psychiatry
Disease Progression
Schizophrenia

Keywords

  • Pursuit
  • Saccade
  • Vestibulo-ocular reflex

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Eye Movement Research in the Twenty-First Century—a Window to the Brain, Mind, and More. / Shaikh, Aasef G.; Zee, David Samuel.

In: Cerebellum, 19.12.2017, p. 1-7.

Research output: Contribution to journalArticle

@article{2baf04490b8f469985a024c6fd8b2375,
title = "Eye Movement Research in the Twenty-First Century—a Window to the Brain, Mind, and More",
abstract = "The study of eye movements not only addresses debilitating neuro-ophthalmological problems but has become an essential tool of basic neuroscience research. Eye movements are a classic way to evaluate brain function—traditionally in disorders affecting the brainstem and cerebellum. Abnormalities of eye movements have localizing value and help narrow the differential diagnosis of complex neurological problems. More recently, using sophisticated behavioral paradigms, measurement of eye movements has also been applied to disorders of the thalamus, basal ganglia, and cerebral cortex. Moreover, in contemporary neuroscience, eye movements play a key role in understanding cognition, behavior, and disorders of the mind. Examples include applications to higher-level decision-making processes as in neuroeconomics and psychiatric and cognitive disorders such as schizophrenia and autism. Eye movements have become valued as objective biomarkers to monitor the natural progression of disease and the effects of therapies. As specific genetic defects are identified for many neurological disorders, ocular motor function often becomes the cornerstone of phenotypic classification and differential diagnosis. Here, we introduce other important applications of eye movement research, including understanding movement disorders affecting the head and limbs. We also emphasize the need to develop standardized test batteries for eye movements of all types including the vestibulo-ocular responses. The evaluation and treatment of patients with cerebellar ataxia are particularly amenable to such an approach.",
keywords = "Pursuit, Saccade, Vestibulo-ocular reflex",
author = "Shaikh, {Aasef G.} and Zee, {David Samuel}",
year = "2017",
month = "12",
day = "19",
doi = "10.1007/s12311-017-0910-5",
language = "English (US)",
pages = "1--7",
journal = "Cerebellum",
issn = "1473-4222",
publisher = "Springer New York",

}

TY - JOUR

T1 - Eye Movement Research in the Twenty-First Century—a Window to the Brain, Mind, and More

AU - Shaikh, Aasef G.

AU - Zee, David Samuel

PY - 2017/12/19

Y1 - 2017/12/19

N2 - The study of eye movements not only addresses debilitating neuro-ophthalmological problems but has become an essential tool of basic neuroscience research. Eye movements are a classic way to evaluate brain function—traditionally in disorders affecting the brainstem and cerebellum. Abnormalities of eye movements have localizing value and help narrow the differential diagnosis of complex neurological problems. More recently, using sophisticated behavioral paradigms, measurement of eye movements has also been applied to disorders of the thalamus, basal ganglia, and cerebral cortex. Moreover, in contemporary neuroscience, eye movements play a key role in understanding cognition, behavior, and disorders of the mind. Examples include applications to higher-level decision-making processes as in neuroeconomics and psychiatric and cognitive disorders such as schizophrenia and autism. Eye movements have become valued as objective biomarkers to monitor the natural progression of disease and the effects of therapies. As specific genetic defects are identified for many neurological disorders, ocular motor function often becomes the cornerstone of phenotypic classification and differential diagnosis. Here, we introduce other important applications of eye movement research, including understanding movement disorders affecting the head and limbs. We also emphasize the need to develop standardized test batteries for eye movements of all types including the vestibulo-ocular responses. The evaluation and treatment of patients with cerebellar ataxia are particularly amenable to such an approach.

AB - The study of eye movements not only addresses debilitating neuro-ophthalmological problems but has become an essential tool of basic neuroscience research. Eye movements are a classic way to evaluate brain function—traditionally in disorders affecting the brainstem and cerebellum. Abnormalities of eye movements have localizing value and help narrow the differential diagnosis of complex neurological problems. More recently, using sophisticated behavioral paradigms, measurement of eye movements has also been applied to disorders of the thalamus, basal ganglia, and cerebral cortex. Moreover, in contemporary neuroscience, eye movements play a key role in understanding cognition, behavior, and disorders of the mind. Examples include applications to higher-level decision-making processes as in neuroeconomics and psychiatric and cognitive disorders such as schizophrenia and autism. Eye movements have become valued as objective biomarkers to monitor the natural progression of disease and the effects of therapies. As specific genetic defects are identified for many neurological disorders, ocular motor function often becomes the cornerstone of phenotypic classification and differential diagnosis. Here, we introduce other important applications of eye movement research, including understanding movement disorders affecting the head and limbs. We also emphasize the need to develop standardized test batteries for eye movements of all types including the vestibulo-ocular responses. The evaluation and treatment of patients with cerebellar ataxia are particularly amenable to such an approach.

KW - Pursuit

KW - Saccade

KW - Vestibulo-ocular reflex

UR - http://www.scopus.com/inward/record.url?scp=85038380742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038380742&partnerID=8YFLogxK

U2 - 10.1007/s12311-017-0910-5

DO - 10.1007/s12311-017-0910-5

M3 - Article

C2 - 29260439

AN - SCOPUS:85038380742

SP - 1

EP - 7

JO - Cerebellum

JF - Cerebellum

SN - 1473-4222

ER -