Eye Movement Disorders and the Cerebellum

Ari A. Shemesh, David S. Zee

Research output: Contribution to journalArticle

Abstract

The cerebellum works as a network hub for optimizing eye movements through its mutual connections with the brainstem and beyond. Here, we review three key areas in the cerebellum that are related to the control of eye movements: (1) the flocculus/paraflocculus (tonsil) complex, primarily for high-frequency, transient vestibular responses, and also for smooth pursuit maintenance and steady gaze holding; (2) the nodulus/ventral uvula, primarily for low-frequency, sustained vestibular responses; and (3) the dorsal vermis/posterior fastigial nucleus, primarily for the accuracy of saccades. Although there is no absolute compartmentalization of function within the three major ocular motor areas in the cerebellum, the structural-functional approach provides a framework for assessing ocular motor performance in patients with disease that involves the cerebellum or the brainstem.

Original languageEnglish (US)
Pages (from-to)405-414
Number of pages10
JournalJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Volume36
Issue number6
DOIs
StatePublished - Nov 1 2019

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Ocular Motility Disorders
Cerebellum
Eye Movements
Brain Stem
Uvula
Smooth Pursuit
Cerebellar Diseases
Cerebellar Nuclei
Saccades
Palatine Tonsil
Motor Cortex
Maintenance

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Eye Movement Disorders and the Cerebellum. / Shemesh, Ari A.; Zee, David S.

In: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, Vol. 36, No. 6, 01.11.2019, p. 405-414.

Research output: Contribution to journalArticle

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