Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients

W. J. Freed, Joel Kleinman, C. N. Karson, S. G. Potkin, D. L. Murphy, R. J. Wyatt

Research output: Contribution to journalArticle

Abstract

The present findings suggest a correlation between platelet MAO activity and central dopaminergic activity as reflected by eye-blink rates. Although the relationship between platelet MAO and brain MAO is unknown, it is of interest that dopamine is a substrate for human MAO from both tissues (Glover et al., 1977). Beyond this, the basis for the relationship between platelet MAO activity and eye-blinking is unknown. However, it is not unreasonable to expect that brain MAO, as reflected by MAO activity in platelets, exerts some influence on brain dopamine or other monoamines such as to influence eye-blinking and possibly other behaviors as well.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalBiological Psychiatry
Volume15
Issue number2
StatePublished - 1980
Externally publishedYes

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Monoamine Oxidase
Blood Platelets
Blinking
Dopamine
Brain

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Freed, W. J., Kleinman, J., Karson, C. N., Potkin, S. G., Murphy, D. L., & Wyatt, R. J. (1980). Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients. Biological Psychiatry, 15(2), 329-332.

Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients. / Freed, W. J.; Kleinman, Joel; Karson, C. N.; Potkin, S. G.; Murphy, D. L.; Wyatt, R. J.

In: Biological Psychiatry, Vol. 15, No. 2, 1980, p. 329-332.

Research output: Contribution to journalArticle

Freed, WJ, Kleinman, J, Karson, CN, Potkin, SG, Murphy, DL & Wyatt, RJ 1980, 'Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients', Biological Psychiatry, vol. 15, no. 2, pp. 329-332.
Freed, W. J. ; Kleinman, Joel ; Karson, C. N. ; Potkin, S. G. ; Murphy, D. L. ; Wyatt, R. J. / Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients. In: Biological Psychiatry. 1980 ; Vol. 15, No. 2. pp. 329-332.
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