Eye banking and corneal transplantation communicable adverse incidents: Current status and project NOTIFY

Paul J. Dubord, G. Dewey Evans, Marian S. MacSai, Mark J. Mannis, David B. Glasser, Douglas M. Strong, Luc Noël, Deirdre Fehily

Research output: Contribution to journalArticle

Abstract

PURPOSE: Evidence of the transmission of disease via donor ocular tissue has been demonstrated for adenocarcincoma, rabies, hepatitis B virus, cytomegalovirus, herpes simplex virus, Creutzfeldt-Jakob disease, and a variety of bacterial and fungal infections. METHODS: Although there is no evidence to date of disease transmission for HIV infection, syphilis, hepatitis C, hepatitis A, tuberculosis, HTLV-1 and -2 infection, active leprosy, active typhoid, smallpox, and active malaria, these entities remain contraindications for transplantation for all eye banks nationally and internationally. The potential sources of contamination include infected donors, during the process of removing tissue from cadaveric donors, the processing environment, and contaminated supplies and reagents used during processing. The transmissions of Herpes simplex virus and HSV via corneal graft have been shown to be responsible for primary graft failure. HSV-1 may also be an important cause of PFG. RESULTS: The long latency period of some diseases, the emergence of new infectious disease, and the reemergence of others emphasize the need for long-term record maintenance and effective tracing capabilities. CONCLUSIONS: The standardization of definitions for adverse events and reactions will be necessary to support the prevention and transmission of disease. International classification of a unique identification system for donors will be increasingly important for vigilance and traceability in cross-national exportation of human cells, tissues, and cellular- and tissue-based products. Opportunities for continuous improvement exist as does the need for constant vigilance and surveillance.

Original languageEnglish (US)
Pages (from-to)1155-1166
Number of pages12
JournalCornea
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • American trypanosomiasis
  • Creutzfeldt-Jakob disease (CJD)
  • Eye Bank Technical Advisory Group (EBTAG)
  • West Nile Virus
  • adverse events and reactions
  • biovigilance
  • chikungunya virus
  • corneal transplantation
  • endophthalmitis and microbial keratitis
  • hepatitis B and C
  • herpesviridae
  • human immunodeficiency virus (HIV) I and II
  • malignancy
  • primary graft failure (PGF)
  • project NOTIFY
  • rabies
  • syphilis
  • trypanosoma Cruzi
  • tuberculosis

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Dubord, P. J., Evans, G. D., MacSai, M. S., Mannis, M. J., Glasser, D. B., Strong, D. M., Noël, L., & Fehily, D. (2013). Eye banking and corneal transplantation communicable adverse incidents: Current status and project NOTIFY. Cornea, 32(8), 1155-1166. https://doi.org/10.1097/ICO.0b013e31828f9d64