Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells

Kang Chen, Liqun Wu, Zack Z. Wang

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease is one of leading causes of death throughout the U.S. and the world. The damage of cardiomyocytes resulting from ischemic injury is irreversible and leads to the development of progressive heart failure, which is characterized by the loss of functional cardiomyocytes. Because cardiomyocytes are unable to regenerate in the adult heart, cell-based therapy of transplantation provides a potential alternative approach to replace damaged myocardial tissue and restore cardiac function. A major roadblock toward this goal is the lack of donor cells; therefore, it is urgent to identify the cardiovascular cells that are necessary for achieving cardiac muscle regeneration. Pluripotent embryonic stem (ES) cells have enormous potential as a source of therapeutic tissues, including cardiovascular cells; however, the regulatory elements mediating ES cell differentiation to cardiomyocytes are largely unknown. In this review, we will focus on extrinsic factors that play a role in regulating different stages of cardiomyocyte differentiation of ES cells.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalJournal of Cellular Biochemistry
Volume104
Issue number1
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Embryonic Stem Cells
Stem cells
Cardiac Myocytes
Tissue
Muscle
Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Regeneration
Cell Differentiation
Cause of Death
Myocardium
Cardiovascular Diseases
Heart Failure
Transplantation
Wounds and Injuries
Therapeutics

Keywords

  • Cardiomyocyte
  • Differentiation
  • Embryonic stem cells
  • Extrinsic factor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells. / Chen, Kang; Wu, Liqun; Wang, Zack Z.

In: Journal of Cellular Biochemistry, Vol. 104, No. 1, 01.05.2008, p. 119-128.

Research output: Contribution to journalArticle

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