Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells

Kang Chen, Liqun Wu, Zack Z. Wang

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Cardiovascular disease is one of leading causes of death throughout the U.S. and the world. The damage of cardiomyocytes resulting from ischemic injury is irreversible and leads to the development of progressive heart failure, which is characterized by the loss of functional cardiomyocytes. Because cardiomyocytes are unable to regenerate in the adult heart, cell-based therapy of transplantation provides a potential alternative approach to replace damaged myocardial tissue and restore cardiac function. A major roadblock toward this goal is the lack of donor cells; therefore, it is urgent to identify the cardiovascular cells that are necessary for achieving cardiac muscle regeneration. Pluripotent embryonic stem (ES) cells have enormous potential as a source of therapeutic tissues, including cardiovascular cells; however, the regulatory elements mediating ES cell differentiation to cardiomyocytes are largely unknown. In this review, we will focus on extrinsic factors that play a role in regulating different stages of cardiomyocyte differentiation of ES cells.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalJournal of cellular biochemistry
Issue number1
StatePublished - May 1 2008
Externally publishedYes


  • Cardiomyocyte
  • Differentiation
  • Embryonic stem cells
  • Extrinsic factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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