Extraprostatic extension of prostatic adenocarcinoma on needle core biopsy

Report of 72 cases with clinical follow-up

Jeremy S. Miller, Yingbei Chen, Huihui Ye, Brian D. Robinson, Fadi Brimo, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

OBJECTIVE To describe the histological findings and prognosis that are associated with extraprostatic extension (EPE) on needle core biopsy of prostatic adenocarcinoma. PATIENTS AND METHODS We retrieved 99 cases of prostatic adenocarcinoma with EPE at initial diagnosis on biopsy from the consultation files of one of the authors between 1997 and 2009. The 72 cases that had available clinical follow-up data formed the basis of this study. RESULTS The mean (range) age of the patients was 64 (48-87) years, the median (mean, range) serum prostatic specific antigen level was 7.8 (64.8, 0.3-1505) ng/mL, and 60 of the patients (83%) had abnormalities on a digital rectal examination. The mean (range) number of malignant cores was 7.7 (1-23); the mean percentage of carcinoma in each core was 69.6%, and that in the core(s) with EPE was 76.8%. The mean Gleason score in the core(s) with EPE was 8, with a mean highest Gleason score per case of 8.4. Perineural invasion was detected in 54 cases (75%). Ten of 11 patients treated surgically had EPE on the radical prostatectomy (RP) specimen; also six had positive resection margins, five showed invasion into the seminal vesicles and one had lymph node metastasis. The Gleason scores in nine of the RP specimens did not differ from the highest grade found in the associated biopsies (score 9 in three, 8 in two, 7 in four); in one case it increased (from score 6 to 8) and in one it decreased (from score 9 to 8). Patients were followed for a mean (median, range) of 2.9 (2, 0.1-9) years, with metastases identified in 29 (40%); 10 (14%) died from the disease. CONCLUSION EPE on needle core biopsy of the prostate is strongly associated with extensive, high-grade prostatic adenocarcinoma, such that its usefulness as an isolated prognostic factor is relatively limited.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalBJU International
Volume106
Issue number3
DOIs
StatePublished - Aug 2010

Fingerprint

Large-Core Needle Biopsy
Neoplasm Grading
Adenocarcinoma
Prostatectomy
Neoplasm Metastasis
Biopsy
Digital Rectal Examination
Seminal Vesicles
Prostate
Referral and Consultation
Lymph Nodes
Carcinoma
Antigens
Serum

Keywords

  • Extraprostatic extension
  • Needle core biopsy
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Extraprostatic extension of prostatic adenocarcinoma on needle core biopsy : Report of 72 cases with clinical follow-up. / Miller, Jeremy S.; Chen, Yingbei; Ye, Huihui; Robinson, Brian D.; Brimo, Fadi; Epstein, Jonathan Ira.

In: BJU International, Vol. 106, No. 3, 08.2010, p. 330-333.

Research output: Contribution to journalArticle

Miller, Jeremy S. ; Chen, Yingbei ; Ye, Huihui ; Robinson, Brian D. ; Brimo, Fadi ; Epstein, Jonathan Ira. / Extraprostatic extension of prostatic adenocarcinoma on needle core biopsy : Report of 72 cases with clinical follow-up. In: BJU International. 2010 ; Vol. 106, No. 3. pp. 330-333.
@article{ca7425c09b554c79ade884134194ccfd,
title = "Extraprostatic extension of prostatic adenocarcinoma on needle core biopsy: Report of 72 cases with clinical follow-up",
abstract = "OBJECTIVE To describe the histological findings and prognosis that are associated with extraprostatic extension (EPE) on needle core biopsy of prostatic adenocarcinoma. PATIENTS AND METHODS We retrieved 99 cases of prostatic adenocarcinoma with EPE at initial diagnosis on biopsy from the consultation files of one of the authors between 1997 and 2009. The 72 cases that had available clinical follow-up data formed the basis of this study. RESULTS The mean (range) age of the patients was 64 (48-87) years, the median (mean, range) serum prostatic specific antigen level was 7.8 (64.8, 0.3-1505) ng/mL, and 60 of the patients (83{\%}) had abnormalities on a digital rectal examination. The mean (range) number of malignant cores was 7.7 (1-23); the mean percentage of carcinoma in each core was 69.6{\%}, and that in the core(s) with EPE was 76.8{\%}. The mean Gleason score in the core(s) with EPE was 8, with a mean highest Gleason score per case of 8.4. Perineural invasion was detected in 54 cases (75{\%}). Ten of 11 patients treated surgically had EPE on the radical prostatectomy (RP) specimen; also six had positive resection margins, five showed invasion into the seminal vesicles and one had lymph node metastasis. The Gleason scores in nine of the RP specimens did not differ from the highest grade found in the associated biopsies (score 9 in three, 8 in two, 7 in four); in one case it increased (from score 6 to 8) and in one it decreased (from score 9 to 8). Patients were followed for a mean (median, range) of 2.9 (2, 0.1-9) years, with metastases identified in 29 (40{\%}); 10 (14{\%}) died from the disease. CONCLUSION EPE on needle core biopsy of the prostate is strongly associated with extensive, high-grade prostatic adenocarcinoma, such that its usefulness as an isolated prognostic factor is relatively limited.",
keywords = "Extraprostatic extension, Needle core biopsy, Prostate cancer",
author = "Miller, {Jeremy S.} and Yingbei Chen and Huihui Ye and Robinson, {Brian D.} and Fadi Brimo and Epstein, {Jonathan Ira}",
year = "2010",
month = "8",
doi = "10.1111/j.1464-410X.2009.09110.x",
language = "English (US)",
volume = "106",
pages = "330--333",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Extraprostatic extension of prostatic adenocarcinoma on needle core biopsy

T2 - Report of 72 cases with clinical follow-up

AU - Miller, Jeremy S.

AU - Chen, Yingbei

AU - Ye, Huihui

AU - Robinson, Brian D.

AU - Brimo, Fadi

AU - Epstein, Jonathan Ira

PY - 2010/8

Y1 - 2010/8

N2 - OBJECTIVE To describe the histological findings and prognosis that are associated with extraprostatic extension (EPE) on needle core biopsy of prostatic adenocarcinoma. PATIENTS AND METHODS We retrieved 99 cases of prostatic adenocarcinoma with EPE at initial diagnosis on biopsy from the consultation files of one of the authors between 1997 and 2009. The 72 cases that had available clinical follow-up data formed the basis of this study. RESULTS The mean (range) age of the patients was 64 (48-87) years, the median (mean, range) serum prostatic specific antigen level was 7.8 (64.8, 0.3-1505) ng/mL, and 60 of the patients (83%) had abnormalities on a digital rectal examination. The mean (range) number of malignant cores was 7.7 (1-23); the mean percentage of carcinoma in each core was 69.6%, and that in the core(s) with EPE was 76.8%. The mean Gleason score in the core(s) with EPE was 8, with a mean highest Gleason score per case of 8.4. Perineural invasion was detected in 54 cases (75%). Ten of 11 patients treated surgically had EPE on the radical prostatectomy (RP) specimen; also six had positive resection margins, five showed invasion into the seminal vesicles and one had lymph node metastasis. The Gleason scores in nine of the RP specimens did not differ from the highest grade found in the associated biopsies (score 9 in three, 8 in two, 7 in four); in one case it increased (from score 6 to 8) and in one it decreased (from score 9 to 8). Patients were followed for a mean (median, range) of 2.9 (2, 0.1-9) years, with metastases identified in 29 (40%); 10 (14%) died from the disease. CONCLUSION EPE on needle core biopsy of the prostate is strongly associated with extensive, high-grade prostatic adenocarcinoma, such that its usefulness as an isolated prognostic factor is relatively limited.

AB - OBJECTIVE To describe the histological findings and prognosis that are associated with extraprostatic extension (EPE) on needle core biopsy of prostatic adenocarcinoma. PATIENTS AND METHODS We retrieved 99 cases of prostatic adenocarcinoma with EPE at initial diagnosis on biopsy from the consultation files of one of the authors between 1997 and 2009. The 72 cases that had available clinical follow-up data formed the basis of this study. RESULTS The mean (range) age of the patients was 64 (48-87) years, the median (mean, range) serum prostatic specific antigen level was 7.8 (64.8, 0.3-1505) ng/mL, and 60 of the patients (83%) had abnormalities on a digital rectal examination. The mean (range) number of malignant cores was 7.7 (1-23); the mean percentage of carcinoma in each core was 69.6%, and that in the core(s) with EPE was 76.8%. The mean Gleason score in the core(s) with EPE was 8, with a mean highest Gleason score per case of 8.4. Perineural invasion was detected in 54 cases (75%). Ten of 11 patients treated surgically had EPE on the radical prostatectomy (RP) specimen; also six had positive resection margins, five showed invasion into the seminal vesicles and one had lymph node metastasis. The Gleason scores in nine of the RP specimens did not differ from the highest grade found in the associated biopsies (score 9 in three, 8 in two, 7 in four); in one case it increased (from score 6 to 8) and in one it decreased (from score 9 to 8). Patients were followed for a mean (median, range) of 2.9 (2, 0.1-9) years, with metastases identified in 29 (40%); 10 (14%) died from the disease. CONCLUSION EPE on needle core biopsy of the prostate is strongly associated with extensive, high-grade prostatic adenocarcinoma, such that its usefulness as an isolated prognostic factor is relatively limited.

KW - Extraprostatic extension

KW - Needle core biopsy

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=77955751478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955751478&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.2009.09110.x

DO - 10.1111/j.1464-410X.2009.09110.x

M3 - Article

VL - 106

SP - 330

EP - 333

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 3

ER -