TY - JOUR
T1 - Extraperitoneal Lesions in Feline Infectious Peritonitis
AU - Montali, R. J.
AU - Strandberg, J. D.
N1 - Funding Information:
This investigation was supported by U.S. Public Health Service research grant FR 001 30 and U.S. Public Health Service training grant FR 05010.
PY - 1972/3
Y1 - 1972/3
N2 - Twelve cats with pathologic diagnoses of feline infectious peritonitis were studied. The lesions were primarily extraserosal. This pathologic syndrome was characterized by granulomatous inflammation in a variety of organs, but principally affected the kidneys, visceral lymph nodes, lungs, liver, eyes, and leptomeninges. Histologically, the granulomas were composed of mixtures of neutrophils, lymphocytes, plasma cells, and large spindleshaped histiocytes, and contained areas of necrosis. Inflamed superficial and deep pulmonary and renal cortical veins, the latter often thrombosed, were consistently detected. Phlebitis was also present in other organs, but to a lesser degree. Cell-free tissue extracts from one cat produced clinical and pathologic changes compatible with those originally described for feline infectious peritonitis. Observations of these natural and induced cases show that this form of the disease with disseminated granulomas and minimal serosal lesions may progress by vascular routes.
AB - Twelve cats with pathologic diagnoses of feline infectious peritonitis were studied. The lesions were primarily extraserosal. This pathologic syndrome was characterized by granulomatous inflammation in a variety of organs, but principally affected the kidneys, visceral lymph nodes, lungs, liver, eyes, and leptomeninges. Histologically, the granulomas were composed of mixtures of neutrophils, lymphocytes, plasma cells, and large spindleshaped histiocytes, and contained areas of necrosis. Inflamed superficial and deep pulmonary and renal cortical veins, the latter often thrombosed, were consistently detected. Phlebitis was also present in other organs, but to a lesser degree. Cell-free tissue extracts from one cat produced clinical and pathologic changes compatible with those originally described for feline infectious peritonitis. Observations of these natural and induced cases show that this form of the disease with disseminated granulomas and minimal serosal lesions may progress by vascular routes.
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U2 - 10.1177/030098587200900204
DO - 10.1177/030098587200900204
M3 - Article
C2 - 4677655
AN - SCOPUS:0015470174
SN - 0300-9858
VL - 9
SP - 109
EP - 121
JO - Veterinary pathology
JF - Veterinary pathology
IS - 2
ER -