Extrahelical damaged base recognition by DNA glycosylase enzymes

Research output: Contribution to journalArticlepeer-review

Abstract

The efficient enzymatic detection of damaged bases concealed in the DNA double helix is an essential step during DNA repair in all cells. Emergent structural and mechanistic approaches have provided glimpses into this enigmatic molecular recognition event in several systems. A ubiquitous feature of these essential reactions is the binding of the damaged base in an extrahelical binding mode. The reaction pathway by which this remarkable extrahelical state is achieved is of great interest and even more debate.

Original languageEnglish (US)
Pages (from-to)786-793
Number of pages8
JournalChemistry - A European Journal
Volume14
Issue number3
DOIs
StatePublished - 2008

Keywords

  • Base flipping
  • DNA base dynamics
  • DNA damage
  • DNA glycosylase

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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