Extracellular vesicles-mediated signaling in the osteosarcoma microenvironment: Roles and potential therapeutic targets

Min Lan, Xiao Ping Zhu, Zhi Yuan Cao, Jia Ming Liu, Qing Lin, Zhi Li Liu

Research output: Contribution to journalReview article

Abstract

Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in children. It is usually characterized by a high risk of developing lung metastasis and poor prognosis. Extracellular vesicles (EVs) are cell-derived nanoparticles with a small size of 50–200 nm in diameter. As a communicator, the contents of the EVs secreted via either fusing with lysosomes for degradation and recycling or fusing with the cell plasma membrane into the extracellular environment, which play an important role in regulating the tumor microenvironment of OS and mediating the Wnt/β-catenin and TGF-β signalings. Increasing evidences suggest that EVs have significant role in OS growth, progression, metastasis and drug resistance. In this study, the roles of EVs in the physiology and pathogenesis of OS and the potential attractive therapeutic target for the treatment of OS were reviewed.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalJournal of Bone Oncology
Volume12
DOIs
StatePublished - Sep 1 2018

Fingerprint

Osteosarcoma
Cell Membrane
Neoplasm Metastasis
Therapeutics
Catenins
Tumor Microenvironment
Recycling
Lysosomes
Drug Resistance
Nanoparticles
Extracellular Vesicles
Bone and Bones
Lung
Growth
Neoplasms

Keywords

  • Extracellular vesicles
  • Osteosarcoma
  • Tgf-β
  • Tumor microenvironment
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Oncology

Cite this

Extracellular vesicles-mediated signaling in the osteosarcoma microenvironment : Roles and potential therapeutic targets. / Lan, Min; Zhu, Xiao Ping; Cao, Zhi Yuan; Liu, Jia Ming; Lin, Qing; Liu, Zhi Li.

In: Journal of Bone Oncology, Vol. 12, 01.09.2018, p. 101-104.

Research output: Contribution to journalReview article

Lan, Min ; Zhu, Xiao Ping ; Cao, Zhi Yuan ; Liu, Jia Ming ; Lin, Qing ; Liu, Zhi Li. / Extracellular vesicles-mediated signaling in the osteosarcoma microenvironment : Roles and potential therapeutic targets. In: Journal of Bone Oncology. 2018 ; Vol. 12. pp. 101-104.
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