Extracellular vesicles for research on psychiatric disorders

Shin Ichi Kano; Eisuke Dohi; Indigo V.L. Rose

doi:10.1093/schbul/sby127

Extracellular vesicles for research on psychiatric disorders

Shin Ichi Kano, Eisuke Dohi, Indigo V.L. Rose

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.

Original language	English (US)
Pages (from-to)	7-16
Number of pages	10
Journal	Schizophrenia bulletin
Volume	45
Issue number	1
DOIs	https://doi.org/10.1093/schbul/sby127
State	Published - Jan 1 2019
Externally published	Yes

Keywords

Biomarker
EVs
Exosome
Extracellular vesicle
Intercellular communication
Microvesicle
Psychiatric disorders
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1093/schbul/sby127

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abstract = "Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.",

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AU - Kano, Shin Ichi

AU - Dohi, Eisuke

AU - Rose, Indigo V.L.

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AB - Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.

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KW - Psychiatric disorders

KW - Schizophrenia

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Extracellular vesicles for research on psychiatric disorders

Abstract

Keywords

ASJC Scopus subject areas

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