Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Qian Wu; Wen Zhen Duan; Jian Bei Chen; Xiao Peng Zhao; Xiao Juan Li; Yue Yun Liu; Qing Yu Ma; Zhe Xue; Jia Xu Chen

doi:10.3389/fphar.2022.843412

Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Qian Wu, Wen Zhen Duan, Jian Bei Chen, Xiao Peng Zhao, Xiao Juan Li, Yue Yun Liu, Qing Yu Ma, Zhe Xue, Jia Xu Chen

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.

Original language	English (US)
Article number	843412
Journal	Frontiers in Pharmacology
Volume	13
DOIs	https://doi.org/10.3389/fphar.2022.843412
State	Published - Mar 24 2022

Keywords

depressive disorder
ectosomes
exosomes
extracellular vehicles
herbal therapies
microvescicles
phytochemials

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

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10.3389/fphar.2022.843412

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title = "Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder",

abstract = "Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.",

keywords = "depressive disorder, ectosomes, exosomes, extracellular vehicles, herbal therapies, microvescicles, phytochemials",

author = "Qian Wu and Duan, {Wen Zhen} and Chen, {Jian Bei} and Zhao, {Xiao Peng} and Li, {Xiao Juan} and Liu, {Yue Yun} and Ma, {Qing Yu} and Zhe Xue and Chen, {Jia Xu}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Wu, Duan, Chen, Zhao, Li, Liu, Ma, Xue and Chen.",

year = "2022",

month = mar,

day = "24",

doi = "10.3389/fphar.2022.843412",

language = "English (US)",

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T2 - Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

AU - Wu, Qian

AU - Duan, Wen Zhen

AU - Chen, Jian Bei

AU - Zhao, Xiao Peng

AU - Li, Xiao Juan

AU - Liu, Yue Yun

AU - Ma, Qing Yu

AU - Xue, Zhe

AU - Chen, Jia Xu

PY - 2022/3/24

Y1 - 2022/3/24

N2 - Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.

AB - Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.

KW - depressive disorder

KW - ectosomes

KW - exosomes

KW - extracellular vehicles

KW - herbal therapies

KW - microvescicles

KW - phytochemials

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DO - 10.3389/fphar.2022.843412

M3 - Review article

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AN - SCOPUS:85128176061

SN - 1663-9812

VL - 13

JO - Frontiers in Pharmacology

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Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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