Extracellular potassium and blood flow in the post-ischemic rat brain

A. J. Hansen, A. Gjedde, E. Siemkowicz

Research output: Contribution to journalArticlepeer-review

Abstract

The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]3 decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+-K+-ATPase.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume389
Issue number1
DOIs
StatePublished - Dec 1 1980

Keywords

  • Cerebral blood flow
  • Cerebral ischemia
  • Extracellular potassium

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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