Abstract
For over a century, embryologists who studied cellular motion in early amniotes generally assumed that morphogenetic movement reflected migration relative to a static extracellular matrix (ECM) scaffold. However, as we discuss in this Review, recent investigations reveal that the ECM is also moving during morphogenesis. Time-lapse studies show how convective tissue displacement patterns, as visualized by ECM markers, contribute to morphogenesis and organogenesis. Computational image analysis distinguishes between cell-autonomous (active) displacements and convection caused by large-scale (composite) tissue movements. Modern quantification of large-scale ‘total’ cellular motion and the accompanying ECM motion in the embryo demonstrates that a dynamic ECM is required for generation of the emergent motion patterns that drive amniote morphogenesis.
Original language | English (US) |
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Pages (from-to) | 2056-2065 |
Number of pages | 10 |
Journal | Development (Cambridge) |
Volume | 143 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2016 |
Externally published | Yes |
Keywords
- Amniote morphogenesis
- Emergent patterns
- Extracellular matrix dynamics
- Tissue-scale motion
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology