Extracellular matrix motion and early morphogenesis

Rajprasad Loganathan, Brenda J. Rongish, Christopher M. Smith, Michael B. Filla, Andras Czirok, Bertrand Bénazéraf, Charles D. Little

Research output: Contribution to journalReview article

Abstract

For over a century, embryologists who studied cellular motion in early amniotes generally assumed that morphogenetic movement reflected migration relative to a static extracellular matrix (ECM) scaffold. However, as we discuss in this Review, recent investigations reveal that the ECM is also moving during morphogenesis. Time-lapse studies show how convective tissue displacement patterns, as visualized by ECM markers, contribute to morphogenesis and organogenesis. Computational image analysis distinguishes between cell-autonomous (active) displacements and convection caused by large-scale (composite) tissue movements. Modern quantification of large-scale ‘total’ cellular motion and the accompanying ECM motion in the embryo demonstrates that a dynamic ECM is required for generation of the emergent motion patterns that drive amniote morphogenesis.

Original languageEnglish (US)
Pages (from-to)2056-2065
Number of pages10
JournalDevelopment (Cambridge)
Volume143
Issue number12
DOIs
StatePublished - Jun 15 2016

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Morphogenesis
Extracellular Matrix
Convection
Organogenesis
Embryonic Structures

Keywords

  • Amniote morphogenesis
  • Emergent patterns
  • Extracellular matrix dynamics
  • Tissue-scale motion

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Loganathan, R., Rongish, B. J., Smith, C. M., Filla, M. B., Czirok, A., Bénazéraf, B., & Little, C. D. (2016). Extracellular matrix motion and early morphogenesis. Development (Cambridge), 143(12), 2056-2065. https://doi.org/10.1242/dev.127886

Extracellular matrix motion and early morphogenesis. / Loganathan, Rajprasad; Rongish, Brenda J.; Smith, Christopher M.; Filla, Michael B.; Czirok, Andras; Bénazéraf, Bertrand; Little, Charles D.

In: Development (Cambridge), Vol. 143, No. 12, 15.06.2016, p. 2056-2065.

Research output: Contribution to journalReview article

Loganathan, R, Rongish, BJ, Smith, CM, Filla, MB, Czirok, A, Bénazéraf, B & Little, CD 2016, 'Extracellular matrix motion and early morphogenesis', Development (Cambridge), vol. 143, no. 12, pp. 2056-2065. https://doi.org/10.1242/dev.127886
Loganathan R, Rongish BJ, Smith CM, Filla MB, Czirok A, Bénazéraf B et al. Extracellular matrix motion and early morphogenesis. Development (Cambridge). 2016 Jun 15;143(12):2056-2065. https://doi.org/10.1242/dev.127886
Loganathan, Rajprasad ; Rongish, Brenda J. ; Smith, Christopher M. ; Filla, Michael B. ; Czirok, Andras ; Bénazéraf, Bertrand ; Little, Charles D. / Extracellular matrix motion and early morphogenesis. In: Development (Cambridge). 2016 ; Vol. 143, No. 12. pp. 2056-2065.
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