TY - JOUR
T1 - Extracellular Matrix
T2 - Functions in the nervous system
AU - Barros, Claudia S.
AU - Franco, Santos J.
AU - Müller, Ulrich
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system.
AB - An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system.
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U2 - 10.1101/cshperspect.a005108
DO - 10.1101/cshperspect.a005108
M3 - Article
C2 - 21123393
AN - SCOPUS:84863871371
VL - 3
SP - 1
EP - 24
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 1
ER -