Extra sensory perception: The role of Gpr receptors in the kidney

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalCurrent Opinion in Nephrology and Hypertension
Volume23
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Kidney
Odorant Receptors
Ligands
Sensory Receptor Cells
G-Protein-Coupled Receptors
Cell Biology

Keywords

  • chemoreceptor
  • kidney
  • olfactory receptor
  • ORs
  • renal

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine
  • Medicine(all)

Cite this

Extra sensory perception : The role of Gpr receptors in the kidney. / Pluznick, Jennifer.

In: Current Opinion in Nephrology and Hypertension, Vol. 23, No. 5, 2014, p. 507-512.

Research output: Contribution to journalArticle

@article{e386d24d6f5c41c48fa0fd800700dc2d,
title = "Extra sensory perception: The role of Gpr receptors in the kidney",
abstract = "PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.",
keywords = "chemoreceptor, kidney, olfactory receptor, ORs, renal",
author = "Jennifer Pluznick",
year = "2014",
doi = "10.1097/MNH.0000000000000048",
language = "English (US)",
volume = "23",
pages = "507--512",
journal = "Current Opinion in Nephrology and Hypertension",
issn = "1062-4821",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Extra sensory perception

T2 - The role of Gpr receptors in the kidney

AU - Pluznick, Jennifer

PY - 2014

Y1 - 2014

N2 - PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.

AB - PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.

KW - chemoreceptor

KW - kidney

KW - olfactory receptor

KW - ORs

KW - renal

UR - http://www.scopus.com/inward/record.url?scp=84906099906&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906099906&partnerID=8YFLogxK

U2 - 10.1097/MNH.0000000000000048

DO - 10.1097/MNH.0000000000000048

M3 - Article

C2 - 25023949

AN - SCOPUS:84906099906

VL - 23

SP - 507

EP - 512

JO - Current Opinion in Nephrology and Hypertension

JF - Current Opinion in Nephrology and Hypertension

SN - 1062-4821

IS - 5

ER -