Extra sensory perception: The role of Gpr receptors in the kidney

Research output: Contribution to journalReview articlepeer-review

Abstract

PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Volume23
Issue number5
DOIs
StatePublished - Sep 2014

Keywords

  • ORs
  • chemoreceptor
  • kidney
  • olfactory receptor
  • renal

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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