TY - JOUR
T1 - Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men
T2 - Multicenter AIDS Cohort Study
AU - Rezaeian, Panteha
AU - Miller, P. Elliott
AU - Haberlen, Sabina A.
AU - Razipour, Aryabod
AU - Bahrami, Hossein
AU - Castillo, Romeo
AU - Witt, Mallory D.
AU - Kingsley, Lawrence
AU - Palella, Frank J.
AU - Nakanishi, Rine
AU - Matsumoto, Suguru
AU - Alani, Anas
AU - Jacobson, Lisa P.
AU - Post, Wendy S.
AU - Budoff, Matthew J.
N1 - Publisher Copyright:
© 2016 Society of Cardiovascular Computed Tomography
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Introduction Previous studies have demonstrated an association between HIV infection and coronary artery disease (CAD); little is known about potential associations between HIV infection and extra-coronary calcification (ECC). Methods We analyzed 621 HIV infected (HIV+) and 384 HIV uninfected (HIV−) men from the Multicenter AIDS Cohort Study who underwent non-contrast computed tomography (CT) from 2010-2013. Agatston scores were calculated for mitral annular calcification (MAC), aortic valve calcification (AVC), aortic valve ring calcification (AVRC), and thoracic aortic calcification (TAC). The associations between HIV infection and the presence of each type of ECC (score > 0) were evaluated by multivariable logistic regression. We also evaluated the association of ECC with inflammatory biomarker levels and coronary plaque morphology. Results Among HIV+ and HIV− men, the age-standardized prevalences were 15% for TAC (HIV+ 14%/HIV− 16%), 10% for AVC (HIV+ 11%/HIV− 8%), 24% for AVRC (HIV+ 23% HIV− 24%), and 5% for MAC (HIV+ 7%/HIV− 3%). After adjustment, HIV+ men had 3-fold greater odds of MAC compared to HIV− men (OR = 3.2, 95% CI: 1.5–6.7), and almost twice the odds of AVC (1.8, 1.1–2.9). HIV serostatus was not associated with TAC or AVRC. AVRC was associated with higher Il-6 and sCD163 levels. TAC was associated with higher ICAM-1, TNF-α RII, and Il-6 levels. AVC and AVRC calcification were associated with presence of non-calcified plaque in HIV+ but not HIV− men. Conclusion HIV infection is an independent predictor of MAC and AVC. Whether these calcifications predict mortality in HIV+ patients deserves further investigation.
AB - Introduction Previous studies have demonstrated an association between HIV infection and coronary artery disease (CAD); little is known about potential associations between HIV infection and extra-coronary calcification (ECC). Methods We analyzed 621 HIV infected (HIV+) and 384 HIV uninfected (HIV−) men from the Multicenter AIDS Cohort Study who underwent non-contrast computed tomography (CT) from 2010-2013. Agatston scores were calculated for mitral annular calcification (MAC), aortic valve calcification (AVC), aortic valve ring calcification (AVRC), and thoracic aortic calcification (TAC). The associations between HIV infection and the presence of each type of ECC (score > 0) were evaluated by multivariable logistic regression. We also evaluated the association of ECC with inflammatory biomarker levels and coronary plaque morphology. Results Among HIV+ and HIV− men, the age-standardized prevalences were 15% for TAC (HIV+ 14%/HIV− 16%), 10% for AVC (HIV+ 11%/HIV− 8%), 24% for AVRC (HIV+ 23% HIV− 24%), and 5% for MAC (HIV+ 7%/HIV− 3%). After adjustment, HIV+ men had 3-fold greater odds of MAC compared to HIV− men (OR = 3.2, 95% CI: 1.5–6.7), and almost twice the odds of AVC (1.8, 1.1–2.9). HIV serostatus was not associated with TAC or AVRC. AVRC was associated with higher Il-6 and sCD163 levels. TAC was associated with higher ICAM-1, TNF-α RII, and Il-6 levels. AVC and AVRC calcification were associated with presence of non-calcified plaque in HIV+ but not HIV− men. Conclusion HIV infection is an independent predictor of MAC and AVC. Whether these calcifications predict mortality in HIV+ patients deserves further investigation.
KW - Coronary plaque morphology
KW - Extra-coronary calcification
KW - HIV
KW - Inflammatory biomarkers
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U2 - 10.1016/j.jcct.2016.02.002
DO - 10.1016/j.jcct.2016.02.002
M3 - Article
C2 - 26949197
AN - SCOPUS:84959266812
SN - 1934-5925
VL - 10
SP - 229
EP - 236
JO - Journal of cardiovascular computed tomography
JF - Journal of cardiovascular computed tomography
IS - 3
ER -