Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder

Levent Kirisci, Ralph Tarter, Ty Ridenour, Maureen Reynolds, Michelle Horner, Michael Vanyukov

Research output: Contribution to journalArticle

Abstract

Background: Psychological items discriminating children of fathers diagnosed with an illicit drug-related substance use disorder and normal controls are indicators of a unidimensional construct termed transmissible liability index (TLI) (Vanyukov et al., 2009). TLI is a highly heritable (Vanyukov et al., 2009; Hicks, Iacono, McGue, 2012) and valid (Vanyukov et al., 2009; Hicks et al., 2009; Kirisci et al., 2013a) measure of childhood liability to substance use disorders (SUDs). Aims: This longitudinal study determined whether TLI has incremental validity for predicting SUD beyond commonly measured psychological indicators of risk. Methods: TLI and measures of executive cognitive capacity, emotion dysregulation and externalizing disturbance were administered to boys at ages 10-12 and 16. SUD outcome determined at age 22 was assessed as (1) any SUD, (2) the number of drug-specific SUDs, and (3) SUD severity. Results: TLI predicted SUD beyond the contribution of measures of emotion dysregulation, executive cognitive capacity and externalizing disturbance. The association of emotion dysregulation and externalizing behavior at ages 10-12 and 16 with SUD at age 22 was also reduced to non-significance after controlling for transmissible risk measured by TLI. Conclusions: TLI's incremental validity beyond these latter indicators of risk points to its utility for identifying vulnerable youths requiring intervention.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalAddictive Behaviors
Volume42
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Substance-Related Disorders
Emotions
Street Drugs
Pharmaceutical Preparations
Psychology
Fathers
Longitudinal Studies

Keywords

  • Children
  • Family history
  • Risk
  • Substance use disorder
  • Vulnerability

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Toxicology
  • Medicine (miscellaneous)

Cite this

Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder. / Kirisci, Levent; Tarter, Ralph; Ridenour, Ty; Reynolds, Maureen; Horner, Michelle; Vanyukov, Michael.

In: Addictive Behaviors, Vol. 42, 01.03.2015, p. 57-62.

Research output: Contribution to journalArticle

Kirisci, Levent ; Tarter, Ralph ; Ridenour, Ty ; Reynolds, Maureen ; Horner, Michelle ; Vanyukov, Michael. / Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder. In: Addictive Behaviors. 2015 ; Vol. 42. pp. 57-62.
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