### Abstract

A class of estimating functions is proposed for the estimation of multivariate relative risk in stratified case-control studies. It reduces to the well-known Mantel-Haenszel estimator when there is a single binary risk factor. Large-sample properties of the solutions to the proposed estimating equations are established for two distinct situations. Efficiency calculations suggest that the proposed estimators are nearly fully efficient relative to the conditional maximum likelihood estimator for the parameters considered. Application of the proposed method to family data and longitudinal data, where the conditional likelihood approach fails, is discussed. Two examples from case-control studies and one example from a study on familial aggregation are presented.

Original language | English (US) |
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Pages (from-to) | 289-299 |

Number of pages | 11 |

Journal | Biometrics |

Volume | 43 |

Issue number | 2 |

State | Published - 1986 |

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### ASJC Scopus subject areas

- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
- Applied Mathematics
- Statistics and Probability
- Public Health, Environmental and Occupational Health

### Cite this

*Biometrics*,

*43*(2), 289-299.