Extended IL10 haplotypes and their association with HIV progression to AIDS

T. K. Oleksyk, S. Shrestha, A. L. Truelove, J. J. Goedert, S. M. Donfield, J. Phair, Shruti Hemendra Mehta, S. J. O'Brien, M. W. Smith

Research output: Contribution to journalArticle

Abstract

Interleukin-10 (IL-10) is a pleiotropic cytokine with both immunosuppressive and immunostimulatory functions. Its roles in infections and autoimmunity may have resulted in selective pressures on polymorphisms within the gene, leading to genomic coexistence of several semi-conserved haplotypes involved with diverse pathogen interactions during genomic evolution. Previous studies focused either exclusively on promoter haplotypes or on individual SNPs. We genotyped 21 single nucleotide polymorphisms in the human IL10 gene and examined this variation compared to other mammalian species sequences. Haplotype heterogeneity in human populations is centered around 'classic' 'proximal' promoter polymorphisms: -592, -819 and -1082. High-producing GCC haplotypes are by far the most numerous and diverse group, the intermediate IL-10 producing ACC-inclusive haplotypes seem to be related most closely to the ancestral haplotype, and the ATA-inclusive haplotypes cluster a separate branch with strong bootstrap support. We looked at associations of corresponding haplotypes with HIV progression. A haplotype trend regression confirmed that individuals carrying the low-producing ATA-inclusive haplotypes in European Americans progress to AIDS faster, and most likely explain the role of IL10. Our findings are consistent with the hypothesis that existing polymorphisms in this gene may reflect a balance of historic adaptive responses to autoimmune, infectious and other disease agents.

Original languageEnglish (US)
Pages (from-to)309-322
Number of pages14
JournalGenes and Immunity
Volume10
Issue number4
DOIs
Publication statusPublished - Mar 20 2009

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ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Oleksyk, T. K., Shrestha, S., Truelove, A. L., Goedert, J. J., Donfield, S. M., Phair, J., ... Smith, M. W. (2009). Extended IL10 haplotypes and their association with HIV progression to AIDS. Genes and Immunity, 10(4), 309-322. https://doi.org/10.1038/gene.2009.9