Expression patterns of VEGF and Flk-1 in human endometrium during the menstrual cycle

Tsung Hsuan Lai, Nikos Vlahos, Ie Ming Shih, Yulian Zhao

Research output: Contribution to journalArticle

Abstract

Background: The VEGF is essential in the process of tissue remodeling and angiogenesis. Limited data is available on the expression and regulation of VEGF and its receptors in the human endometrium. The aim of this study was evaluation of expression patterns of VEGF and Flk-1 in human endometrium during the menstrual cycle. Methods: Sixty paraffin-embedded blocks of endometrial tissues from the patients with normal menstrual cycles were obtained. Tissue samples were assembled into tissue microarray slides and classified by histological dating into five phases: the proliferative (n=14), peri-ovulatory (n=9), early-secretory (n=12), mid-secretory (n=11) and late-secretory (n=14) phases. Immunohistochemical staining was performed using VEGF or Flk-1 monoclonal antibodies. The intensity of immunostaining was evaluated by the semi-quantitative scoring method (HSCORE). Kruskal-Wallis one-way analysis of variance and Scheff's post-hoc test were used for statistical analysis. A p-value of

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalJournal of Reproduction and Infertility
Volume16
Issue number1
StatePublished - Jan 1 2015

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Menstrual Cycle
Endometrium
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor
Paraffin
Analysis of Variance
Research Design
Monoclonal Antibodies
Staining and Labeling

Keywords

  • Endometrium
  • Flk-1
  • Menstrual cycle
  • Tissue microarray
  • VEGF

ASJC Scopus subject areas

  • Reproductive Medicine

Cite this

Expression patterns of VEGF and Flk-1 in human endometrium during the menstrual cycle. / Lai, Tsung Hsuan; Vlahos, Nikos; Shih, Ie Ming; Zhao, Yulian.

In: Journal of Reproduction and Infertility, Vol. 16, No. 1, 01.01.2015, p. 3-9.

Research output: Contribution to journalArticle

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