Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: A serial analysis

A. Stüber, R. Martin, L. A. Stone, H. Maloni, H. F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4+ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalJournal of Neuroimmunology
Volume66
Issue number1-2
DOIs
StatePublished - May 1996
Externally publishedYes

Keywords

  • fluorescence activated cell sorting (FACS)
  • lymphocyte subsets
  • magnetic resonance imaging (MRI)
  • multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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