Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: A serial analysis

A. Stüber; R. Martin; L. A. Stone; H. Maloni; H. F. McFarland

doi:10.1016/0165-5728(96)00026-4

Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: A serial analysis

A. Stüber, R. Martin, L. A. Stone, H. Maloni, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4⁺ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	66
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(96)00026-4
State	Published - May 1996
Externally published	Yes

Keywords

fluorescence activated cell sorting (FACS)
lymphocyte subsets
magnetic resonance imaging (MRI)
multiple sclerosis

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/0165-5728(96)00026-4

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title = "Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: A serial analysis",

abstract = "We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4+ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.",

keywords = "fluorescence activated cell sorting (FACS), lymphocyte subsets, magnetic resonance imaging (MRI), multiple sclerosis",

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year = "1996",

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T1 - Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients

T2 - A serial analysis

AU - Stüber, A.

AU - Martin, R.

AU - Stone, L. A.

AU - Maloni, H.

AU - McFarland, H. F.

PY - 1996/5

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AB - We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4+ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.

KW - fluorescence activated cell sorting (FACS)

KW - lymphocyte subsets

KW - magnetic resonance imaging (MRI)

KW - multiple sclerosis

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Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: A serial analysis

Abstract

Keywords

ASJC Scopus subject areas

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