Expression of transforming growth factor-beta 1 in human bladder cancer

H. Miyamoto, Y. Kubota, T. Shuin, S. Torigoe, Y. Dobashi, M. Hosaka

Research output: Contribution to journalArticle

Abstract

Background. Elevated expression of transforming growth factor-beta 1 (TGF- β1) has been reported in several types of human cancer. However, the significance of TGF-β1 expression in clinical bladder cancer is not well known. Methods. The levels of TGF-β1 expression were quantitated using a polymerase chain reaction-based method in tissue specimens obtained from 51 patients with bladder cancer. Results. Transforming growth factor-beta 1 expression in bladder cancer was higher than that found in normal bladder epithelium (P <0.01). Significantly higher levels of TGF-β1 transcripts were observed in low and intermediate grade (Grade 1 and 2) tumors than in high grade (Grade 3) tumors (P <0.02). Superficial (pTa and pT1) tumors had higher levels of TGF-β1 than invasive (pT2 or higher) tumors (P <0.05). Conclusions. These results suggest that enhanced expression of TGF-β1 is specific to low grade and stage bladder cancer. Transforming growth factor- beta 1 may play an important role in the early stages of human bladder cancer development, and TGF-β1 expression could provide a new relevant tumor marker for determining tumor progression in patients with bladder cancer.

Original languageEnglish (US)
Pages (from-to)2565-2570
Number of pages6
JournalCancer
Volume75
Issue number10
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Transforming Growth Factor beta
Neoplasms
Tumor Biomarkers
Urinary Bladder
Epithelium
Polymerase Chain Reaction

Keywords

  • bladder cancer
  • polymerase chain reaction
  • T-24 cells
  • transforming growth factor-β1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression of transforming growth factor-beta 1 in human bladder cancer. / Miyamoto, H.; Kubota, Y.; Shuin, T.; Torigoe, S.; Dobashi, Y.; Hosaka, M.

In: Cancer, Vol. 75, No. 10, 1995, p. 2565-2570.

Research output: Contribution to journalArticle

Miyamoto, H, Kubota, Y, Shuin, T, Torigoe, S, Dobashi, Y & Hosaka, M 1995, 'Expression of transforming growth factor-beta 1 in human bladder cancer', Cancer, vol. 75, no. 10, pp. 2565-2570. https://doi.org/10.1002/1097-0142(19950515)75:10<2565::AID-CNCR2820751025>3.0.CO;2-M
Miyamoto, H. ; Kubota, Y. ; Shuin, T. ; Torigoe, S. ; Dobashi, Y. ; Hosaka, M. / Expression of transforming growth factor-beta 1 in human bladder cancer. In: Cancer. 1995 ; Vol. 75, No. 10. pp. 2565-2570.
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