Expression of teratoma-associated antigens on murine ova and early embryos. Identification of two early differentiation markers

Linda R. Gooding, Yu Chih Hsu, Michael A Edidin

Research output: Contribution to journalArticle

Abstract

Specifically absorbed rabbit antisera to a mouse testicular teratoma were used to study the expression of three heteroantigens on cell surfaces of early mouse embryos. This antiserum is known to define three antigens on the surface of murine tumor cells, though it does not bind to cells of normal adult tissue. Antigen I, physically associated with H-2 antigens in L-cell plasma membranes and found on many transplantable mouse tumors (7), is expressed by ova and morulae. Antigen I persists on cells of the inner-cell mass beyond implantation, but is not detected on trophoblast. In contrast, antigen II, found on teratoma and hepatoma cells, is absent from cleavage embryos and is first expressed on differentiation of the trophoblast prior to implantation. Antigen III, which is apparently teratoma specific, is absent from all embryonic material studied.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalDevelopmental Biology
Volume49
Issue number2
DOIs
StatePublished - 1976

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Differentiation Antigens
Teratoma
Ovum
Embryonic Structures
Antigens
Trophoblasts
Immune Sera
Cell Membrane
H-2 Antigens
Heterophile Antigens
Morula
Surface Antigens
Hepatocellular Carcinoma
Neoplasms
Rabbits

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Expression of teratoma-associated antigens on murine ova and early embryos. Identification of two early differentiation markers. / Gooding, Linda R.; Hsu, Yu Chih; Edidin, Michael A.

In: Developmental Biology, Vol. 49, No. 2, 1976, p. 479-486.

Research output: Contribution to journalArticle

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