Expression of RNA of an Endogenous Replication-Defective Retrovirus in Rat Mammary Adenocarcinomas Induced by 7, 12-Dimethylbenz[a]anthracene

Howard A. Young, Martin L. Wenk, Dawn G. Goodman, Edward M. Scolnick

Research output: Contribution to journalArticle

Abstract

An investigation into the possible relationship between chemical carcinogen Induction of rat mammary tumors and the expression of an endogenous retroviral genome was initiated. Mammary tumors were induced in female SD rats with 7, 12-dlmethylbenz[a]anthracene (DMBA). Tumors, Identified histologically as mammary adenocarcinomas, were analyzed for RNA of a replication-defective endogenous retrovirus or RNA of a helper-independent endogenous type C virus. Expression of RNA of the replication-defective virus was detected in mammary tumors weighing 0.2-2.0 g. Larger tumors, for which histologic examination revealed proportionally more fibroblastic tissue than epithelial cells, did not contain comparable concentrations of this viral RNA. RNA homologous to a helper-independent rat type C retrovirus was not detected In tumors of any size. A cell line was established from a primary DMBA-induced mammary adenocarcinoma and appeared similar to the small mammary tumors with respect to endogenous type C viral RNA expression. We discuss possible Implications of the expression of endogenous replication-defective viruses for use as markers for the effects of chemical carcinogens.—J Natl Cancer Inst 61: 1329-1337, 1978.

Original languageEnglish (US)
Pages (from-to)1329-1337
Number of pages9
JournalJournal of the National Cancer Institute
Volume61
Issue number5
DOIs
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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