TY - JOUR
T1 - Expression of PAX3 in Ewing's sarcoma family of tumors
AU - Schulte, Theodor W.
AU - Toretsky, Jeffrey A.
AU - Ress, Elisabeth
AU - Helman, Lee
AU - Neckers, Leonard M.
N1 - Funding Information:
We gratefully thank Dr. David Shapiro (St. Jude Research Hospital, Memphis, TN) for PAX3 antiserum and Pax3 cDNA. This project was supported by the Cooperative Human Tissue Network, which is funded by the National Cancer Institute.
PY - 1997/4
Y1 - 1997/4
N2 - The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal development of neural crest cells and is involved in the t(2; 13) translocation found in alveolar rhabdomyosarcoma. Since ESFTs are believed to be derived from neural crest tissue, we screened a series of Ewing's sarcoma and peripheral neuroectodermal tumor cell lines and tumor specimens for expression of PAX3. We found expression of PAX3 in most, but not all, of the specimens analyzed, including cell lines and patient material.
AB - The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal development of neural crest cells and is involved in the t(2; 13) translocation found in alveolar rhabdomyosarcoma. Since ESFTs are believed to be derived from neural crest tissue, we screened a series of Ewing's sarcoma and peripheral neuroectodermal tumor cell lines and tumor specimens for expression of PAX3. We found expression of PAX3 in most, but not all, of the specimens analyzed, including cell lines and patient material.
UR - http://www.scopus.com/inward/record.url?scp=0031127217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031127217&partnerID=8YFLogxK
U2 - 10.1006/bmme.1997.2567
DO - 10.1006/bmme.1997.2567
M3 - Article
C2 - 9169092
AN - SCOPUS:0031127217
SN - 1077-3150
VL - 60
SP - 121
EP - 126
JO - Biochemical and Molecular Medicine
JF - Biochemical and Molecular Medicine
IS - 2
ER -