Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma

Phyu P. Aung; Yen Chun Liu; Leomar Y. Ballester; Paul F. Robbins; Steven A. Rosenberg; Chyi Chia Richard Lee

doi:10.1016/j.humpath.2013.05.029

Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma

Phyu P. Aung, Yen Chun Liu, Leomar Y. Ballester, Paul F. Robbins, Steven A. Rosenberg, Chyi Chia Richard Lee

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous findings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma.

Original language	English (US)
Pages (from-to)	259-267
Number of pages	9
Journal	Human pathology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/j.humpath.2013.05.029
State	Published - Feb 2014
Externally published	Yes

Keywords

Cancer testis antigen
Immunotherapy
Melanoma
NY-ESO-1

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2013.05.029

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title = "Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma",

abstract = "New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous findings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma.",

keywords = "Cancer testis antigen, Immunotherapy, Melanoma, NY-ESO-1",

author = "Aung, {Phyu P.} and Liu, {Yen Chun} and Ballester, {Leomar Y.} and Robbins, {Paul F.} and Rosenberg, {Steven A.} and Lee, {Chyi Chia Richard}",

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AU - Aung, Phyu P.

AU - Liu, Yen Chun

AU - Ballester, Leomar Y.

AU - Robbins, Paul F.

AU - Rosenberg, Steven A.

AU - Lee, Chyi Chia Richard

PY - 2014/2

Y1 - 2014/2

N2 - New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous findings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma.

AB - New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous findings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma.

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Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma

Abstract

Keywords

ASJC Scopus subject areas

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