Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma

Phyu P. Aung, Yen Chun Liu, Leomar Y. Ballester, Paul F. Robbins, Steven A. Rosenberg, Chyi Chia Richard Lee

Research output: Contribution to journalArticlepeer-review

Abstract

New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous findings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalHuman pathology
Volume45
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Cancer testis antigen
  • Immunotherapy
  • Melanoma
  • NY-ESO-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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