Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

J. W R Mulder, V. J M Wielenga, M. M. Polak, F. M. Van Den Berg, G. R. Adolf, P. Herrlich, S. T. Pals, G. J A Offerhaus

Research output: Contribution to journalArticle

Abstract

Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalGut
Volume36
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Mutant Proteins
Adenoma
Carcinogenesis
Carcinoma
Cell Adhesion Molecules
Tumor Biomarkers
Tumor Suppressor Genes
Molecular Biology
Mucous Membrane
Proteins
Immunohistochemistry

Keywords

  • Adenoma
  • Cancer
  • CD44
  • Colon
  • p53

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Mulder, J. W. R., Wielenga, V. J. M., Polak, M. M., Van Den Berg, F. M., Adolf, G. R., Herrlich, P., ... Offerhaus, G. J. A. (1995). Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. Gut, 36(1), 76-80.

Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. / Mulder, J. W R; Wielenga, V. J M; Polak, M. M.; Van Den Berg, F. M.; Adolf, G. R.; Herrlich, P.; Pals, S. T.; Offerhaus, G. J A.

In: Gut, Vol. 36, No. 1, 1995, p. 76-80.

Research output: Contribution to journalArticle

Mulder, JWR, Wielenga, VJM, Polak, MM, Van Den Berg, FM, Adolf, GR, Herrlich, P, Pals, ST & Offerhaus, GJA 1995, 'Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis', Gut, vol. 36, no. 1, pp. 76-80.
Mulder JWR, Wielenga VJM, Polak MM, Van Den Berg FM, Adolf GR, Herrlich P et al. Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. Gut. 1995;36(1):76-80.
Mulder, J. W R ; Wielenga, V. J M ; Polak, M. M. ; Van Den Berg, F. M. ; Adolf, G. R. ; Herrlich, P. ; Pals, S. T. ; Offerhaus, G. J A. / Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis. In: Gut. 1995 ; Vol. 36, No. 1. pp. 76-80.
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