Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

J. W R Mulder, V. J M Wielenga, M. M. Polak, F. M. Van Den Berg, G. R. Adolf, P. Herrlich, S. T. Pals, G. J A Offerhaus

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalGut
Volume36
Issue number1
StatePublished - 1995
Externally publishedYes

Keywords

  • Adenoma
  • Cancer
  • CD44
  • Colon
  • p53

ASJC Scopus subject areas

  • Gastroenterology

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