Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer

Mariël Brinkhuis, Miguel A. Izquierdo, Jan P A Baak, Paul J. Van Diest, Peter Kenemans, George L. Scheffer, Rik J. Scheper

Research output: Contribution to journalArticle

Abstract

Mean nuclear area has been consistently shown by different researchers to be a strong and independent prognostic factor in advanced ovarian carcinoma. However, the biological background of the prognostic value of nuclear area remains unclear. Others have found that the multidrug-resistance (MDR) related protein LRP has strong prognostic value. In the present study we have analysed whether the mean nuclear area and LRP are related in tumour tissue of the ovary obtained at the debulking operation before the administration of chemotherapy in 40 patients. The mitotic activity index, volume percentage epithelium, standard deviation of nuclear area and the other MDR-related proteins P-glycoprotein (JSB-1, MRK-16) and MRP have been investigated additionally for correlations and prognostic value. No correlations were found between the morphometrical features and MDR-related proteins. Mean nuclear area tended to be larger in LRP positive tumours, but the correlation was not significant. In multivariate analysis LRP-protein expression and mean nuclear area had independent prognostic value. Further studies are required to elucidate the biological background of the strong prognostic value of mean nuclear area in advanced ovarian cancer.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalAnalytical Cellular Pathology
Volume24
Issue number1
StatePublished - 2002
Externally publishedYes

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P-Glycoproteins
Multiple Drug Resistance
Ovarian Neoplasms
Neoplasms
Mitotic Index
Ovary
Multivariate Analysis
Epithelium
Research Personnel
Carcinoma
Drug Therapy
Proteins

Keywords

  • Carcinoma
  • Morphometry
  • Multi drug resistance
  • Ovary
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Brinkhuis, M., Izquierdo, M. A., Baak, J. P. A., Van Diest, P. J., Kenemans, P., Scheffer, G. L., & Scheper, R. J. (2002). Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer. Analytical Cellular Pathology, 24(1), 17-23.

Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer. / Brinkhuis, Mariël; Izquierdo, Miguel A.; Baak, Jan P A; Van Diest, Paul J.; Kenemans, Peter; Scheffer, George L.; Scheper, Rik J.

In: Analytical Cellular Pathology, Vol. 24, No. 1, 2002, p. 17-23.

Research output: Contribution to journalArticle

Brinkhuis, M, Izquierdo, MA, Baak, JPA, Van Diest, PJ, Kenemans, P, Scheffer, GL & Scheper, RJ 2002, 'Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer', Analytical Cellular Pathology, vol. 24, no. 1, pp. 17-23.
Brinkhuis, Mariël ; Izquierdo, Miguel A. ; Baak, Jan P A ; Van Diest, Paul J. ; Kenemans, Peter ; Scheffer, George L. ; Scheper, Rik J. / Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer. In: Analytical Cellular Pathology. 2002 ; Vol. 24, No. 1. pp. 17-23.
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