Expression of mouse and frog rRNA genes: transcription and processing

Barbara Sollner-Webb, Louise Pape, Kenneth Ryan, Edward B. Mougey, Regina Poretta, Emil Nikolov, Mark H. Paalman, Inara Lazdins, Cathy Martin

Research output: Contribution to journalArticlepeer-review

Abstract

This article summarizes a number of lines of investigation of rRNA gene expression that are ongoing in the laboratory. These studies focus on mouse and frog, two distant vertebrate species. One major conclusion is that the basic properties of rRNA gene expression appear remarkably well conserved in evolution, with only relatively minor perturbations between frog and mouse, contrary to the common interpretation of the species-selectivety between mouse and human rDNA transcription (e.g., 1). This is true both for the process of rDNA transcription and for the subsequent rRNA processing event.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume104
Issue number1-2
DOIs
StatePublished - May 1 1991

Keywords

  • enhances
  • promoter
  • rRNA genes
  • rRNA processing
  • species selectivity for gene expression

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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