Expression of messenger RNAs for peptides and tyrosine hydroxylase in primary sensory neurons that innervate arterial baroreceptors and chemoreceptors

Maria F. Czyzyk-Krzeska, Douglas A. Bayliss, Edward E. Lawson, David E. Millhorn

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Retrograde fiber tracing and in situ hybridization were used to determine expression of mRNAs for preprotachykinin A (ppTA), calcitonin gene related peptide (CGRP), preproenkephalin A (ENK), neuropeptide tyrosine (NPY) and somatostatin (SOM) as well as tyrosine hydroxylase (TH) in the petrosal ganglia primary sensory neurons which innervate carotid sinus baroreceptors and carotid body chemoreceptors. Perfusion of the carotid sinus with the retrogradely transported dye (Fluoro-Gold) labeled primary sensory neurons in petrosal ganglion. Numerous somata in the petrosal ganglion labeled with dye contained mRNAs for all the above peptides, except SOM. Moreover, TH mRNA was found in a substantial number of retrogradely labeled cells in the petrosal ganglion. This study provides information concerning which of the numerous peptides identified in sensory neurons of petrosal ganglion may be involved in modulation of the arterial baroreceptor and chemoreceptor reflexes.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
StatePublished - Aug 5 1991
Externally publishedYes

Keywords

  • Fluoro-Gold
  • Gene expression
  • Glossopharyngeal nerve
  • In situ hybridization
  • Messenger RNA
  • Peptide
  • Petrosal ganglion
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • General Neuroscience

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